PMID- 6321360
OWN - NLM
STAT- MEDLINE
DCOM- 19840424
LR  - 20190708
IS  - 0020-7136 (Print)
IS  - 0020-7136 (Linking)
VI  - 33
IP  - 3
DP  - 1984 Mar 15
TI  - Increased incidence of mouse mammary tumor virus-related antigen in Tunisian 
      patients with breast cancer.
PG  - 305-8
AB  - Biopsies obtained from 74 Tunisian women with breast cancer (33 cases), benign 
      breast disease (17 cases), and cervical cancer (24 cases) were assayed for the 
      presence of an antigen cross-reacting with gp52 of the mouse mammary tumor virus 
      (MMTV) in order to determine the frequency and possible prognostic significance 
      of this antigen in a form of rapidly progressing breast cancer designated poussee 
      evolutive or PEV. Antigen was detected in 23/33 breast carcinomas (70%) but in 
      none of the 41 control specimens. An evaluation of reactivity according to tumor 
      aggressiveness and survival could be performed in retrospect on 29 of the breast 
      cancer patients with a follow-up of up to 11 years. The frequency of gp52-related 
      antigen was similar in the patients with the most aggressive form of PEV with 
      inflammatory signs (8/12 or 67% positive) and those breast cancer patients 
      without PEV (12/17 or 71% positive). Within each of the two groups, PEV+ and PEV 
      0, no correlation was observed between the presence or absence of antigen and the 
      disease-free interval or survival. We conclude that the identification of 
      gp52-related antigens in the breast cancer biopsies from North African women has 
      implications different from those observed in other populations. While thus far 
      not indicative of disease aggressiveness and prognosis, the higher frequency of 
      detectable antigen in comparison to biopsies obtained from patients born in the 
      United States and Europe may have relevance to the etiology and pathogenesis of 
      the disease.
FAU - Levine, P H
AU  - Levine PH
FAU - Mesa-Tejada, R
AU  - Mesa-Tejada R
FAU - Keydar, I
AU  - Keydar I
FAU - Tabbane, F
AU  - Tabbane F
FAU - Spiegelman, S
AU  - Spiegelman S
FAU - Mourali, N
AU  - Mourali N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Antigens, Viral)
RN  - 0 (Antigens, Viral, Tumor)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Viral Envelope Proteins)
RN  - 0 (glycoprotein 52 antigen, Mouse mammary tumor virus)
SB  - IM
MH  - Adenofibroma/immunology
MH  - Adult
MH  - Aged
MH  - Animals
MH  - Antigens, Neoplasm/*analysis
MH  - Antigens, Viral/*analysis
MH  - *Antigens, Viral, Tumor
MH  - Breast Neoplasms/*immunology/mortality/pathology
MH  - Female
MH  - Fibrocystic Breast Disease/immunology
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Immunoglobulin G/analysis
MH  - Mammary Tumor Virus, Mouse/*immunology
MH  - Mice
MH  - Middle Aged
MH  - Prognosis
MH  - Tumor Virus Infections/immunology
MH  - Tunisia
MH  - Uterine Cervical Neoplasms/immunology
MH  - Viral Envelope Proteins/analysis
EDAT- 1984/03/15 00:00
MHDA- 1984/03/15 00:01
CRDT- 1984/03/15 00:00
PHST- 1984/03/15 00:00 [pubmed]
PHST- 1984/03/15 00:01 [medline]
PHST- 1984/03/15 00:00 [entrez]
AID - 10.1002/ijc.2910330305 [doi]
PST - ppublish
SO  - Int J Cancer. 1984 Mar 15;33(3):305-8. doi: 10.1002/ijc.2910330305.