PMID- 6324054
OWN - NLM
STAT- MEDLINE
DCOM- 19840504
LR  - 20210111
IS  - 0304-3959 (Print)
IS  - 0304-3959 (Linking)
VI  - 18
IP  - 1
DP  - 1984 Jan
TI  - Afferent fibers mediate the increase of met-enkephalin elicited in rat spinal 
      cord by localized pain.
PG  - 25-31
LID - 10.1016/0304-3959(84)90123-4 [doi]
AB  - Met-enkephalin levels were measured in various spinal cord regions of rats 
      chronically suffering from the inflammation of a single paw following a treatment 
      with Freund's adjuvant. The results indicate that chronic localized pain induces 
      a selective increase of met-enkephalin immunoreactive material (ME-IR) in the 
      dorsal horn of the spinal cord segment which receives a direct projection from 
      the inflamed paw. In order to gain information on the functional meaning of these 
      data, either the plexus brachialis or the sciatic nerve were sectioned 
      peripherally before inducing inflammation. Denervation prevented the increase of 
      ME-IR concentration induced by the injection of Freund's adjuvant. Our 
      observations suggest that chronic localized pain in a limb induces a change in 
      ME-IR content which is selective for the spinal cord segment receiving a direct 
      projection from the inflamed paw. This increase depends on an intact innervation.
FAU - Faccini, E
AU  - Faccini E
AD  - Department of Pharmacology and Pharmacognosy, University of Milan, Milan, Italy 
      Department of Pharmacology, University of Brescia, BresciaItaly.
FAU - Uzumaki, H
AU  - Uzumaki H
FAU - Govoni, S
AU  - Govoni S
FAU - Missale, C
AU  - Missale C
FAU - Spano, P F
AU  - Spano PF
FAU - Covelli, V
AU  - Covelli V
FAU - Trabucchi, M
AU  - Trabucchi M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pain
JT  - Pain
JID - 7508686
RN  - 58569-55-4 (Enkephalin, Methionine)
RN  - 9007-81-2 (Freund's Adjuvant)
SB  - IM
MH  - Afferent Pathways/physiology
MH  - Animals
MH  - Enkephalin, Methionine/*biosynthesis
MH  - Freund's Adjuvant
MH  - Inflammation/chemically induced
MH  - Male
MH  - Nerve Fibers/physiology
MH  - Pain/etiology/*physiopathology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Spinal Cord/*metabolism
MH  - Synaptic Transmission
EDAT- 1984/01/01 00:00
MHDA- 1984/01/01 00:01
CRDT- 1984/01/01 00:00
PHST- 1984/01/01 00:00 [pubmed]
PHST- 1984/01/01 00:01 [medline]
PHST- 1984/01/01 00:00 [entrez]
AID - 00006396-198401000-00003 [pii]
AID - 10.1016/0304-3959(84)90123-4 [doi]
PST - ppublish
SO  - Pain. 1984 Jan;18(1):25-31. doi: 10.1016/0304-3959(84)90123-4.