PMID- 6327073
OWN - NLM
STAT- MEDLINE
DCOM- 19840723
LR  - 20190705
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 37
IP  - 2
DP  - 1984 Jun
TI  - Tumorigenesis by mouse mammary tumor virus: proviral activation of a cellular 
      gene in the common integration region int-2.
PG  - 529-36
AB  - Approximately 50% of tumors induced by mouse mammary tumor virus (MMTV) contain 
      an acquired provirus within a limited region of chromosomal DNA, termed int-2. We 
      have extended our previous characterization of this locus and have mapped 
      provirus integration sites in 21 independent tumors. Although integration occurs 
      at multiple sites, proviruses within int-2 are distributed into two oppositely 
      oriented groups whose transcription is directed away from a central domain. 
      Provirus insertion in int-2 is accompanied by expression of RNA derived, at least 
      in part, from this central domain. Since the RNA is not detected in normal 
      mammary tissue, we conclude that MMTV integration activates the expression of a 
      cellular gene within int-2 and that this event may contribute to tumorigenesis.
FAU - Dickson, C
AU  - Dickson C
FAU - Smith, R
AU  - Smith R
FAU - Brookes, S
AU  - Brookes S
FAU - Peters, G
AU  - Peters G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (RNA, Neoplasm)
RN  - EC 3.1.21.- (DNA Restriction Enzymes)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Cloning, Molecular
MH  - DNA Restriction Enzymes
MH  - *Genes, Viral
MH  - Mammary Neoplasms, Experimental/*microbiology
MH  - Mammary Tumor Virus, Mouse/*genetics/pathogenicity
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mutation
MH  - *Oncogenes
MH  - RNA, Neoplasm/genetics
MH  - Transcription, Genetic
EDAT- 1984/06/01 00:00
MHDA- 1984/06/01 00:01
CRDT- 1984/06/01 00:00
PHST- 1984/06/01 00:00 [pubmed]
PHST- 1984/06/01 00:01 [medline]
PHST- 1984/06/01 00:00 [entrez]
AID - 0092-8674(84)90383-0 [pii]
AID - 10.1016/0092-8674(84)90383-0 [doi]
PST - ppublish
SO  - Cell. 1984 Jun;37(2):529-36. doi: 10.1016/0092-8674(84)90383-0.