PMID- 6327481
OWN - NLM
STAT- MEDLINE
DCOM- 19840725
LR  - 20131121
IS  - 0018-5043 (Print)
IS  - 0018-5043 (Linking)
VI  - 16
IP  - 4
DP  - 1984 Apr
TI  - Nephrogenous cyclic adenosine monophosphate levels in normocalcemic cancer 
      patients: its significance.
PG  - 204-7
AB  - We evaluated nephrogenous cyclic adenosine monophosphate ( NcAMP ) levels in 61 
      normocalcemic patients with documented cancer of various organs and cell types. 
      NcAMP levels were elevated in 17 (28%) and decreased in 13 (21%) of the cancer 
      patients. Both high and low NcAMP levels were seen within the various cancer 
      groups. There was a significant correlation (r = 0.383, P less than 0.01) between 
      NcAMP and serum parathyroid hormone (PTH) levels, suggesting that tumor-related 
      factors affecting NcAMP , may be partially related to native PTH. Alternatively, 
      these factors might be altering the effect of endogenous PTH on renal tubules. A 
      significant negative correlation was also observed between NcAMP and tubular 
      maximum for phosphate (r = -0.356, P less than 0.02) suggesting that either cAMP 
      per se or factors affecting NcAMP alter phosphate excretion. Follow up serum 
      calcium data was available on 48 of the 61 patients. Subsequent hypercalcemia 
      developed independent of the initial nephrogenous cAMP levels. It therefore 
      appears that NcAMP elevation and development of hypercalcemia are two separate 
      paraneoplastic phenomena.
FAU - Abramson, E C
AU  - Abramson EC
FAU - Kukreja, S C
AU  - Kukreja SC
FAU - Lad, T E
AU  - Lad TE
FAU - Shemerdiak, W P
AU  - Shemerdiak WP
FAU - York, P A
AU  - York PA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Germany
TA  - Horm Metab Res
JT  - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et 
      metabolisme
JID - 0177722
RN  - 0 (Parathyroid Hormone)
RN  - 0 (Phosphates)
RN  - E0399OZS9N (Cyclic AMP)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Calcium/*blood
MH  - Cyclic AMP/*metabolism
MH  - Female
MH  - Humans
MH  - Kidney/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/*metabolism
MH  - Parathyroid Hormone/blood
MH  - Phosphates/metabolism
EDAT- 1984/04/01 00:00
MHDA- 1984/04/01 00:01
CRDT- 1984/04/01 00:00
PHST- 1984/04/01 00:00 [pubmed]
PHST- 1984/04/01 00:01 [medline]
PHST- 1984/04/01 00:00 [entrez]
AID - 10.1055/s-2007-1014743 [doi]
PST - ppublish
SO  - Horm Metab Res. 1984 Apr;16(4):204-7. doi: 10.1055/s-2007-1014743.