PMID- 6328058
OWN - NLM
STAT- MEDLINE
DCOM- 19840709
LR  - 20190817
IS  - 0047-1828 (Print)
IS  - 0047-1828 (Linking)
VI  - 48
IP  - 5
DP  - 1984 May
TI  - Long-term effects of triiodothyronine and thiouracil on myocardial 
      beta-adrenergic receptor numbers and cyclic AMP concentration in rats.
PG  - 508-14
AB  - Long-term (35 days) effects of thyroid hormone on the number of myocardial 
      beta-adrenergic receptors and the c-AMP concentration were studied in the rat. 
      The ventricles from triiodothyronine-administered rats (T3 rats) showed an 
      increase in the number of beta-receptors compared to controls (54.3 +/- 3.1 vs 
      39.3 +/- 1.8 fmole of [125I]-iodohydroxybenzylpindolol (IHYP) binding sites/mg 
      protein p less than 0.001) on the 35th day. Conversely, the ventricles from 
      thiouracil-administered rats (TU rats) showed a decrease in the number of 
      beta-receptors compared to controls (31.4 +/- 1.6 vs. 38.4 +/- 2.6 fmole/mg 
      protein, p less than 0.05). The equilibrium dissociation constants (Kd) for the 
      interaction of receptors with IHYP did not differ significantly (0.10 to 0.15 
      nM). The myocardial concentration of cyclic AMP was not significantly different 
      (T3 rats, 1.09 +/- 0.09 nM/g wet weight tissue; T3 controls, 1.12 +/- 0.07; TU 
      rats, 1.13 +/- 0.07; TU controls, 1.16 +/- 0.12) on the 35th day. On serial 
      effects of triiodothyronine from the first to the 35th day, the number of 
      beta-receptors of T3 rats increased significantly on the 24th and the 35th day, 
      but the c-AMP concentration was not significantly different from that in control 
      rats. These results demonstrated that thyroid hormone affects the number of 
      myocardial beta-receptors in rats, and suggested a different mechanism of action 
      of thyroid hormone on the myocardium from that of catecholamines.
FAU - Niizoe, K
AU  - Niizoe K
FAU - Ogawa, K
AU  - Ogawa K
FAU - Satake, T
AU  - Satake T
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Jpn Circ J
JT  - Japanese circulation journal
JID - 7806868
RN  - 0 (Receptors, Adrenergic, beta)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 59X161SCYL (Thiouracil)
RN  - E0399OZS9N (Cyclic AMP)
SB  - IM
MH  - Animals
MH  - Body Weight
MH  - Cyclic AMP/*metabolism
MH  - Hyperthyroidism/metabolism
MH  - Hypothyroidism/metabolism
MH  - Male
MH  - Myocardium/*metabolism
MH  - Organ Size
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Adrenergic, beta/analysis/*drug effects
MH  - Thiouracil/*pharmacology
MH  - Triiodothyronine/*pharmacology
EDAT- 1984/05/01 00:00
MHDA- 1984/05/01 00:01
CRDT- 1984/05/01 00:00
PHST- 1984/05/01 00:00 [pubmed]
PHST- 1984/05/01 00:01 [medline]
PHST- 1984/05/01 00:00 [entrez]
AID - 10.1253/jcj.48.508 [doi]
PST - ppublish
SO  - Jpn Circ J. 1984 May;48(5):508-14. doi: 10.1253/jcj.48.508.