PMID- 633139
OWN - NLM
STAT- MEDLINE
DCOM- 19780517
LR  - 20190509
IS  - 0022-3751 (Print)
IS  - 1469-7793 (Electronic)
IS  - 0022-3751 (Linking)
VI  - 275
DP  - 1978 Feb
TI  - A comparison of the action of glutamate, ibotenate and other related amino acids 
      on feline spinal interneurones.
PG  - 449-65
AB  - 1. The effects of microiontophoretically applied glutamate, ibotenate and other 
      related amino acids on the spike activity of feline spinal interneurones were 
      investigated. 2. Unlike the other amino acids, which evoked excitatory responses 
      only, ibotenate evoked slow biphasic responses (excitation-depression) from the 
      majority of these neurones. The depressant action was associated with an increase 
      in spike height and was reversible. 3. The ibotenate depression could be observed 
      as a temporary reduction in background firing rate, a loss of sensitivity to 
      other amino acids, a progressive decrease in the excitatory responses to 
      repetitive ibotenate applications or a fading of excitation following a prolonged 
      administration of ibotenate. 4. The onset of the excitatory effects of glutamate, 
      quisqualate and ibotenate was relatively well fitted by diffusion equations for a 
      continuous point source. However, radial distances for diffusion in the case of 
      ibotenate responses were comparatively greater than those for glutamate and 
      quisqualate. 5. The depressant action of ibotenate was not antagonized by 
      strychnine, picrotoxin or bicuculline. 6. Some methods of quantifying the 
      responses to excitatory amino acids are described. The excitatory potency of 
      quisqualate and N-methyl-D-aspartate was several times greater than that of 
      glutamate. Aspartate and ibotenate were equipotent, while alpha-aminopimelate and 
      alpha-methyl-DL-aspartate were much weaker. 7. It is suggested that the biphasic 
      action of ibotenate on spinal interneurones might be the result of activation of 
      excitatory and inhibitory sites fairly remote from the cell somata where 
      extracellular recordings were probably made.
FAU - MacDonald, J F
AU  - MacDonald JF
FAU - Nistri, A
AU  - Nistri A
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Physiol
JT  - The Journal of physiology
JID - 0266262
RN  - 0 (Glutamates)
RN  - 0 (Oxazoles)
RN  - 0 (Pimelic Acids)
RN  - 2552-55-8 (Ibotenic Acid)
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - SIV03811UC (Kainic Acid)
SB  - IM
MH  - Action Potentials/drug effects
MH  - Animals
MH  - Aspartic Acid/pharmacology
MH  - Cats
MH  - Dose-Response Relationship, Drug
MH  - Glutamates/*pharmacology
MH  - Ibotenic Acid/*pharmacology
MH  - Interneurons/drug effects/*physiology
MH  - Kainic Acid/pharmacology
MH  - Kinetics
MH  - Oxazoles/*pharmacology
MH  - Pimelic Acids/pharmacology
MH  - Spinal Cord/drug effects/*physiology
PMC - PMC1282555
EDAT- 1978/02/01 00:00
MHDA- 1978/02/01 00:01
PMCR- 1978/02/01
CRDT- 1978/02/01 00:00
PHST- 1978/02/01 00:00 [pubmed]
PHST- 1978/02/01 00:01 [medline]
PHST- 1978/02/01 00:00 [entrez]
PHST- 1978/02/01 00:00 [pmc-release]
AID - 10.1113/jphysiol.1978.sp012200 [doi]
PST - ppublish
SO  - J Physiol. 1978 Feb;275:449-65. doi: 10.1113/jphysiol.1978.sp012200.