PMID- 6334152
OWN - NLM
STAT- MEDLINE
DCOM- 19850115
LR  - 20190817
IS  - 0277-2116 (Print)
IS  - 0277-2116 (Linking)
VI  - 3
IP  - 5
DP  - 1984 Nov
TI  - Lymphonodular hyperplasia of the colon as a pathologic finding in children with 
      lower gastrointestinal bleeding.
PG  - 704-8
AB  - The serious implication of gastrointestinal blood loss in children is well 
      recognized; however, the significance of lymphonodular hyperplasia of the colon 
      (LNHC) as a pathologic finding in this group of children is unclear. We reviewed 
      the records of 95 children, ages 2-48 months, who were referred to our clinic 
      with a history of hematochezia. Proctosigmoidoscopy was performed on 65 of them. 
      Twenty children (31%) examined proctosigmoidoscopically were found to have LNHC, 
      with no other identified source of bleeding. Clinical histories, endoscopic 
      findings, and colonic biopsy specimens from the LNHC group were examined. 
      Clinical presentation of patients in this group was not distinctive. LNHC was 
      most prominent in the distal colon and rectum and was endoscopically 
      characterized by friability (13/20) and ulceration (3/20). Characteristics of 
      biopsy specimens from children with LNHC were than compared with tissue obtained 
      from an age-matched control population and children with colitis. Biopsy 
      specimens from children with LNHC contained increased numbers of lymphoid 
      follicles and larger follicles than those from the control group. Specimens also 
      contained mucosal inflammation and epithelial thinning and ulceration overlying 
      enlarged follicles. We conclude that LNHC is a frequent proctosigmoidoscopic 
      finding in children evaluated for lower gastrointestinal bleeding. The endoscopic 
      and histologic appearance of these lesions would suggest that LNHC is not a 
      normal finding and represents a potential source of rectal bleeding in children.
FAU - Kaplan, B
AU  - Kaplan B
FAU - Benson, J
AU  - Benson J
FAU - Rothstein, F
AU  - Rothstein F
FAU - Dahms, B
AU  - Dahms B
FAU - Halpin, T
AU  - Halpin T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pediatr Gastroenterol Nutr
JT  - Journal of pediatric gastroenterology and nutrition
JID - 8211545
SB  - IM
MH  - Acute Disease
MH  - Child, Preschool
MH  - Colitis/complications/pathology
MH  - Colonic Diseases/complications/*pathology
MH  - Female
MH  - Gastrointestinal Hemorrhage/etiology/*pathology
MH  - Humans
MH  - Hyperplasia
MH  - Infant
MH  - Lymph Nodes/*pathology
MH  - Sigmoidoscopy
EDAT- 1984/11/01 00:00
MHDA- 1984/11/01 00:01
CRDT- 1984/11/01 00:00
PHST- 1984/11/01 00:00 [pubmed]
PHST- 1984/11/01 00:01 [medline]
PHST- 1984/11/01 00:00 [entrez]
AID - 10.1097/00005176-198411000-00012 [doi]
PST - ppublish
SO  - J Pediatr Gastroenterol Nutr. 1984 Nov;3(5):704-8. doi: 
      10.1097/00005176-198411000-00012.