PMID- 6337091
OWN - NLM
STAT- MEDLINE
DCOM- 19830317
LR  - 20181113
IS  - 0019-2805 (Print)
IS  - 1365-2567 (Electronic)
IS  - 0019-2805 (Linking)
VI  - 48
IP  - 2
DP  - 1983 Feb
TI  - The expression of surface IgD on B cells responsive to thymus-independent and 
      thymus-dependent antigens and its requirement for B-cell triggering.
PG  - 393-400
AB  - Cells separated by the fluorescence activated cell sorter on the basis of their 
      surface IgD (sIgD) phenotype have been examined for responsiveness to 
      thymus-dependent and thymus-independent antigens. The ability of monoclonal 
      anti-IgD alloantibodies to inhibit responses in vitro to the various classes of 
      antigen has also been investigated. Evidence is presented indicating that both 
      sIgD positive and sIgD negative cells can respond to all types of antigen tested. 
      However, although the presence of sIgD was necessary for the response of sIgD 
      positive cells to thymus-dependent antigens, the presence of this isotype was not 
      obligatory for the response of the sIgD positive population to thymus independent 
      antigens. The possible role of sIgD as the obligatory purveyor of a B-cell 
      activation signal is discussed in the light of these findings.
FAU - Marshall-Clarke, S
AU  - Marshall-Clarke S
FAU - Keeler, K D
AU  - Keeler KD
FAU - Parkhouse, M E
AU  - Parkhouse ME
LA  - eng
PT  - Journal Article
PL  - England
TA  - Immunology
JT  - Immunology
JID - 0374672
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antigens)
RN  - 0 (Immunoglobulin D)
RN  - 0 (Receptors, Antigen, B-Cell)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal/immunology
MH  - Antibody-Producing Cells/immunology
MH  - Antigens/*immunology
MH  - B-Lymphocytes/*immunology
MH  - Cell Separation
MH  - Flow Cytometry
MH  - Hemolytic Plaque Technique
MH  - Immunoglobulin D/*immunology
MH  - Mice
MH  - Mice, Inbred CBA
MH  - Receptors, Antigen, B-Cell/*immunology
MH  - T-Lymphocytes/*immunology
PMC - PMC1453903
EDAT- 1983/02/01 00:00
MHDA- 1983/02/01 00:01
PMCR- 1984/02/01
CRDT- 1983/02/01 00:00
PHST- 1983/02/01 00:00 [pubmed]
PHST- 1983/02/01 00:01 [medline]
PHST- 1983/02/01 00:00 [entrez]
PHST- 1984/02/01 00:00 [pmc-release]
PST - ppublish
SO  - Immunology. 1983 Feb;48(2):393-400.