PMID- 63375
OWN - NLM
STAT- MEDLINE
DCOM- 19770224
LR  - 20031114
IS  - 0014-2980 (Print)
IS  - 0014-2980 (Linking)
VI  - 6
IP  - 11
DP  - 1976 Nov
TI  - Effect of prior sensitization with hapten on the antibovine IgG antibody response 
      to hapten-conjugated tolerogen of mice tolerized by low doses of bovine IgG.
PG  - 810-6
AB  - Mice tolerized by low doses of bovine IgG (BGG), immunized with arsanilated (ARS) 
      conjugates and challenged with ARS-BGG show an augmented anti-BGG antibody 
      response compared with controls immunized with nonconjugated carrier. Conditions 
      optimal for generating hapten help are explored and suggest that the phenomenon 
      is mediated by hapten-specific helper T cells. During exploration of these 
      conditions it became apparent that the response was suppression rather than 
      augmentation with ARS, under certain circumstances, and with 2,4-dinitrophenyl, 
      4-hydroxy-5-iodo-3-nitro-phenylacetyl (NIP) and sulfanilic acid, under all 
      conditions tested. Especially important in determining the outcome of the 
      interaction was the type of adjuvant used for hapten priming. The significance of 
      these observations is discussed in relationship to the balance between negative 
      and positive cooperation.
FAU - Leech, S H
AU  - Leech SH
FAU - Mitchison, N A
AU  - Mitchison NA
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Eur J Immunol
JT  - European journal of immunology
JID - 1273201
RN  - 0 (Antibodies, Anti-Idiotypic)
RN  - 0 (Carrier Proteins)
RN  - 0 (Epitopes)
RN  - 0 (Haptens)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Animals
MH  - Antibodies, Anti-Idiotypic/*biosynthesis
MH  - Carrier Proteins/immunology
MH  - Epitopes
MH  - Female
MH  - *Haptens
MH  - *Immune Tolerance
MH  - *Immunoglobulin G
MH  - *Immunologic Memory
MH  - Kinetics
MH  - Male
MH  - Mice
MH  - Structure-Activity Relationship
MH  - T-Lymphocytes/*immunology
MH  - Time Factors
EDAT- 1976/11/01 00:00
MHDA- 1976/11/01 00:01
CRDT- 1976/11/01 00:00
PHST- 1976/11/01 00:00 [pubmed]
PHST- 1976/11/01 00:01 [medline]
PHST- 1976/11/01 00:00 [entrez]
AID - 10.1002/eji.1830061111 [doi]
PST - ppublish
SO  - Eur J Immunol. 1976 Nov;6(11):810-6. doi: 10.1002/eji.1830061111.