PMID- 6338041
OWN - NLM
STAT- MEDLINE
DCOM- 19830407
LR  - 20190606
IS  - 0021-9738 (Print)
IS  - 0021-9738 (Linking)
VI  - 71
IP  - 3
DP  - 1983 Mar
TI  - Regulation of human immunoglobulin E synthesis in acute graft versus host 
      disease.
PG  - 556-64
AB  - Immunoglobulin (Ig) E synthesis was studied in vitro in eight patients who had 
      received transplants of allogeneic bone marrow. Seven of these patients developed 
      acute graft vs. host disease (GVHD) and elevated serum IgE levels, whereas the 
      eighth did not. In vitro synthesis of IgE, but not of IgG, was elevated in 
      cultures of lymphocytes obtained during acute GVHD (17,923 +/- 14,607 pg/10(6) 
      cells) but not in cultures of lymphocytes obtained after resolution of the acute 
      GVHD when the serum IgE had returned to normal (106 +/- 31 pg/10(6) cells). In 
      contrast, lymphocytes from the patient with no acute GVHD, like normal 
      lymphocytes, failed to synthesize IgE in vitro. The increased in vitro IgE 
      synthesis in acute GVHD was suppressed by normal allogeneic lymphocytes and by 
      autologous lymphocytes obtained after the resolution of the acute GVHD, but not 
      by allogeneic lymphocytes obtained from patients undergoing acute GVHD. The 
      deficiency in functional IgE-specific suppressor cells in acute GVHD occurred in 
      the face of normal or increased percentages of circulating T8+ cells, which in 
      normal subjects contain the IgE-specific suppressor cells. In two patients 
      studied, there was evidence of activated IgE-specific, circulating helper T 
      cells. T cells from these two patients, but not normal T cells, secreted 
      spontaneously upon culture in vitro a factor that induced IgE, but not IgG, 
      synthesis by normal B cells. Finally, a survey of 21 bone marrow transplant 
      recipients revealed that acute GVHD was a necessary requirement for the 
      development of elevated serum IgE levels in recipients of bone marrow 
      transplants. These results suggest that acute GVHD is accompanied by an imbalance 
      in IgE-specific immunoregulatory T cells consisting of activated helper T cells 
      and deficient suppressor cells.
FAU - Saryan, J A
AU  - Saryan JA
FAU - Rappeport, J
AU  - Rappeport J
FAU - Leung, D Y
AU  - Leung DY
FAU - Parkman, R
AU  - Parkman R
FAU - Geha, R S
AU  - Geha RS
LA  - eng
GR  - 5 F32 AM06442-02/AM/NIADDK NIH HHS/United States
GR  - K07-A10440-01/PHS HHS/United States
GR  - RR-128/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Clin Invest
JT  - The Journal of clinical investigation
JID - 7802877
RN  - 0 (Immunoglobulin G)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - B-Lymphocytes/immunology
MH  - Bone Marrow Transplantation
MH  - Female
MH  - *Graft vs Host Reaction
MH  - Humans
MH  - Immunoglobulin E/*biosynthesis
MH  - Immunoglobulin G/biosynthesis
MH  - Infant
MH  - Male
MH  - Middle Aged
MH  - T-Lymphocytes/immunology
PMC - PMC436903
EDAT- 1983/03/01 00:00
MHDA- 1983/03/01 00:01
PMCR- 1983/03/01
CRDT- 1983/03/01 00:00
PHST- 1983/03/01 00:00 [pubmed]
PHST- 1983/03/01 00:01 [medline]
PHST- 1983/03/01 00:00 [entrez]
PHST- 1983/03/01 00:00 [pmc-release]
AID - 10.1172/jci110800 [doi]
PST - ppublish
SO  - J Clin Invest. 1983 Mar;71(3):556-64. doi: 10.1172/jci110800.