PMID- 6340576
OWN - NLM
STAT- MEDLINE
DCOM- 19830505
LR  - 20190619
IS  - 0003-4819 (Print)
IS  - 0003-4819 (Linking)
VI  - 98
IP  - 4
DP  - 1983 Apr
TI  - Predictive factors in chronic graft-versus-host disease in patients with aplastic 
      anemia treated by marrow transplantation from HLA-identical siblings.
PG  - 461-6
AB  - One hundred ten of 175 patients with aplastic anemia conditioned by 
      cyclophosphamide had sustained engraftment of marrow from human leukocyte antigen 
      (HLA)-identical siblings and lived for more than 6 months. Forty-nine of the 110 
      patients developed chronic graft-versus-host disease between 85 and 464 days. 
      Ninety-seven patients are alive from 1.4 to 11 years after engraftment; 13 died 
      between 208 and 726 days. Twenty of the 36 surviving patients with chronic 
      graft-versus-host disease have Karnofsky performance scores of 100%, 7 of 90%, 5 
      of 80%, 1 of 70%, 2 of 60%, and 1 of 40%. Our analysis, using a binary logistic 
      regression model, identified three factors predicting chronic graft-versus-host 
      disease: moderate to severe acute graft-versus-host disease with an estimated 
      relative risk of 11.65; increasing patient age; and the use of viable donor buffy 
      coat cells in addition to the marrow to prevent graft rejection. The last two 
      factors were significant only in patients without acute graft-versus-host 
      disease.
FAU - Storb, R
AU  - Storb R
FAU - Prentice, R L
AU  - Prentice RL
FAU - Sullivan, K M
AU  - Sullivan KM
FAU - Shulman, H M
AU  - Shulman HM
FAU - Deeg, H J
AU  - Deeg HJ
FAU - Doney, K C
AU  - Doney KC
FAU - Buckner, C D
AU  - Buckner CD
FAU - Clift, R A
AU  - Clift RA
FAU - Witherspoon, R P
AU  - Witherspoon RP
FAU - Appelbaum, F A
AU  - Appelbaum FA
FAU - Sanders, J E
AU  - Sanders JE
FAU - Stewart, P S
AU  - Stewart PS
FAU - Thomas, E D
AU  - Thomas ED
LA  - eng
GR  - CA 15704/CA/NCI NIH HHS/United States
GR  - CA 18029/CA/NCI NIH HHS/United States
GR  - CA 30924/CA/NCI NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Ann Intern Med
JT  - Annals of internal medicine
JID - 0372351
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Anemia, Aplastic/*therapy
MH  - *Bone Marrow Transplantation
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Follow-Up Studies
MH  - *Graft vs Host Reaction
MH  - HLA Antigens/analysis
MH  - Humans
MH  - Infant
MH  - Male
MH  - Postoperative Complications/mortality
MH  - Risk
EDAT- 1983/04/01 00:00
MHDA- 1983/04/01 00:01
CRDT- 1983/04/01 00:00
PHST- 1983/04/01 00:00 [pubmed]
PHST- 1983/04/01 00:01 [medline]
PHST- 1983/04/01 00:00 [entrez]
AID - 10.7326/0003-4819-98-4-461 [doi]
PST - ppublish
SO  - Ann Intern Med. 1983 Apr;98(4):461-6. doi: 10.7326/0003-4819-98-4-461.