PMID- 6343433
OWN - NLM
STAT- MEDLINE
DCOM- 19830708
LR  - 20220321
IS  - 0021-9738 (Print)
IS  - 0021-9738 (Linking)
VI  - 71
IP  - 5
DP  - 1983 May
TI  - Prenatal allergic sensitization to helminth antigens in offspring of 
      parasite-infected mothers.
PG  - 1124-9
AB  - Total and filaria-specific immunoglobulin E (IgE) levels were studied in cord 
      blood from infants born in Madras, India, where filariasis and intestinal 
      helminth infections are highly endemic. Increased total IgE levels were observed 
      in 82% of 57 cord sera tested (geometric mean 12.6 ng/ml; range 1-1,900 ng/ml). 
      33 of these sera also contained IgE antibodies specific for filarial antigens as 
      determined by solid-phase radioimmunoassay. Comparison of ratios of 
      filaria-specific IgE to total IgE in paired maternal and cord sera suggested that 
      cord blood IgE was derived from the fetus in most cases and not from 
      transplacental antibody transfer. Our results suggest that prenatal allergic 
      sensitization to helminth parasites occurs in the tropics. Such sensitization may 
      contribute to the heterogeneity in host immune response and disease expression 
      noted in filariasis and other helminth infections.
FAU - Weil, G J
AU  - Weil GJ
FAU - Hussain, R
AU  - Hussain R
FAU - Kumaraswami, V
AU  - Kumaraswami V
FAU - Tripathy, S P
AU  - Tripathy SP
FAU - Phillips, K S
AU  - Phillips KS
FAU - Ottesen, E A
AU  - Ottesen EA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Invest
JT  - The Journal of clinical investigation
JID - 7802877
RN  - 0 (Antigens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Antigens/immunology
MH  - Female
MH  - Fetal Blood/*immunology
MH  - Fetus/*immunology
MH  - Filariasis/*immunology
MH  - Humans
MH  - Immunoglobulin E/*analysis
MH  - India
MH  - Maternal-Fetal Exchange
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/*immunology
MH  - Wuchereria bancrofti/immunology
PMC - PMC436973
EDAT- 1983/05/01 00:00
MHDA- 1983/05/01 00:01
PMCR- 1983/05/01
CRDT- 1983/05/01 00:00
PHST- 1983/05/01 00:00 [pubmed]
PHST- 1983/05/01 00:01 [medline]
PHST- 1983/05/01 00:00 [entrez]
PHST- 1983/05/01 00:00 [pmc-release]
AID - 10.1172/jci110862 [doi]
PST - ppublish
SO  - J Clin Invest. 1983 May;71(5):1124-9. doi: 10.1172/jci110862.