PMID- 6343906
OWN - NLM
STAT- MEDLINE
DCOM- 19830715
LR  - 20181130
IS  - 0028-3835 (Print)
IS  - 0028-3835 (Linking)
VI  - 36
IP  - 5
DP  - 1983 May
TI  - Intracerebroventricular captopril does not inhibit osmotically stimulated 
      vasopressin release.
PG  - 340-6
AB  - Experiments were carried out to determine the effect of intracerebroventricular 
      (icv) administration of the angiotensin-converting enzyme inhibitor, captopril, 
      on osmotically stimulated vasopressin secretion. During icv infusion of captopril 
      (3.1 micrograms/kg . min), dogs were infused intravenously (iv) with either 2.5 
      or 0.15 M NaCl. Control groups received an osmotically equivalent mannitol 
      solution icv with the 2.5 or 0.15 M NaCl iv infusion. As a result of the iv 
      hypertonic saline infusion, plasma vasopressin concentrations increased 
      progressively and in concert with the plasma osmolality; this response was not 
      altered by icv captopril. Plasma vasopressin levels were unchanged during iv 
      isotonic saline infusion, and, again, icv captopril was without effect. At the 
      completion of the icv infusions, injection of angiotensin I icv (310 ng/kg) 
      produced a markedly greater increase in plasma vasopressin levels in animals 
      which had received mannitol icv, compared to those which had received captopril 
      icv. On the basis of these findings, a role for an intrinsic brain 
      renin-angiotensin system, if such a system exists, in the osmotic control of 
      vasopressin secretion is seriously questioned, but not ruled out.
FAU - Hoffman, P K
AU  - Hoffman PK
FAU - Acuff, T E Jr
AU  - Acuff TE Jr
FAU - Share, L
AU  - Share L
FAU - Crofton, J T
AU  - Crofton JT
FAU - Wang, B C
AU  - Wang BC
LA  - eng
GR  - HL-12990/HL/NHLBI NIH HHS/United States
GR  - HL-19209/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Switzerland
TA  - Neuroendocrinology
JT  - Neuroendocrinology
JID - 0035665
RN  - 11000-17-2 (Vasopressins)
RN  - 9DLQ4CIU6V (Proline)
RN  - 9G64RSX1XD (Captopril)
SB  - IM
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Brain/*drug effects
MH  - Captopril/administration & dosage/*pharmacology
MH  - Dogs
MH  - Injections, Intraventricular
MH  - Male
MH  - Osmolar Concentration
MH  - Proline/*analogs & derivatives
MH  - Renin-Angiotensin System/drug effects
MH  - Vasopressins/*metabolism
EDAT- 1983/05/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1983/05/01 00:00
PHST- 1983/05/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1983/05/01 00:00 [entrez]
AID - 10.1159/000123478 [doi]
PST - ppublish
SO  - Neuroendocrinology. 1983 May;36(5):340-6. doi: 10.1159/000123478.