PMID- 6347233
OWN - NLM
STAT- MEDLINE
DCOM- 19830923
LR  - 20191023
IS  - 0007-0971 (Print)
IS  - 0007-0971 (Linking)
VI  - 77
IP  - 2
DP  - 1983 Apr
TI  - Response to oral corticosteroids in chronic airflow obstruction.
PG  - 189-98
AB  - Sixteen Chinese patients with chronic fixed airflow obstruction (mean age 62.5 
      years; mean forced expiratory volume in 1 second (FEV1) of 0.85 litres, and mean 
      ratio FEV1/forced vital capacity (FVC) of 0.45) entered a randomized double-blind 
      crossover trial comparing prednisolone 40 mg orally daily for 2 weeks with 
      placebo. Nine of the 16 patients (56%) had an increase in FEV1 of 15% or more 
      after prednisolone. Compared with placebo, prednisolone significantly improved 
      objective measurements (mean FEV1 by 21.4%, mean FVC by 11.9%, mean daily peak 
      expiratory flow rate by 22.6%), subjective measurement (mean dyspnoea score by 
      16%) and exercise performance assessed by the distance walked in 12 minutes 
      (12MD, by 5.5%). Objective improvements in FEV1 and PEFR were correlated with 
      subjective upgrading of the dyspnoea score, but were not paralleled by an 
      improvement in 12MD. Changes in FVC correlated with neither. FEV1 was thus the 
      best index of objective measurement. The following characteristics were examined 
      for reliability in predicting steroid responsiveness: variability of symptoms, 
      wheezing score, prick skin test positivity, initial bronchodilator response, 
      peripheral blood and sputum eosinophilia, and serum and sputum immunoglobulin E 
      (IgE) level. None was found to be useful. A therapeutic trial of oral 
      corticosteroid should be considered in patients with chronic fixed airflow 
      obstruction on an individual basis.
FAU - Lam, W K
AU  - Lam WK
FAU - So, S Y
AU  - So SY
FAU - Yu, D Y
AU  - Yu DY
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - Br J Dis Chest
JT  - British journal of diseases of the chest
JID - 7511123
RN  - 9PHQ9Y1OLM (Prednisolone)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Aged
MH  - Clinical Trials as Topic
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Lung Diseases, Obstructive/*drug therapy
MH  - Male
MH  - Middle Aged
MH  - Prednisolone/*therapeutic use
MH  - Random Allocation
MH  - Respiratory Function Tests
MH  - Smoking
EDAT- 1983/04/01 00:00
MHDA- 1983/04/01 00:01
CRDT- 1983/04/01 00:00
PHST- 1983/04/01 00:00 [pubmed]
PHST- 1983/04/01 00:01 [medline]
PHST- 1983/04/01 00:00 [entrez]
AID - 10.1016/0007-0971(83)90027-x [doi]
PST - ppublish
SO  - Br J Dis Chest. 1983 Apr;77(2):189-98. doi: 10.1016/0007-0971(83)90027-x.