PMID- 6349381
OWN - NLM
STAT- MEDLINE
DCOM- 19830920
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 245
IP  - 2
DP  - 1983 Aug
TI  - Role of insulin in thermogenic responses to refeeding in 3-day-fasted rats.
PG  - E160-5
AB  - Refeeding 3-day-fasted rats with 40 kJ carbohydrate (CHO; corn flour) or protein 
      (gelatin) caused a rise in plasma insulin levels 3 h later, but refeeding fat or 
      injection of norepinephrine (400 micrograms/kg) had no effect. Injection of 
      insulin (0.25 U) caused a 15% rise in metabolic rate 24 h later in fasted rats 
      that could be inhibited by treatment with propranolol. Refeeding rats with a 
      single CHO meal produced an increase in oxygen consumption (15%) 24 h later that 
      was inhibited by injection of diazoxide or 2-deoxy-D-glucose given at the time of 
      the meal. The thermogenic response to insulin injection was unaffected by 
      treatment with diazoxide or 2-deoxy-D-glucose. Genetically obese Zucker rats 
      failed to increase metabolic rate after insulin or CHO. In normally fed lean 
      rats, maintained on a stock diet or a palatable cafeteria diet, insulin (4 U) 
      enhanced the thermogenic response to norepinephrine and stimulated resting 
      metabolic rate (16%) in the cafeteria-fed rats. These data suggest that insulin 
      is involved in the thermogenic responses to food and catecholamines.
FAU - Rothwell, N J
AU  - Rothwell NJ
FAU - Saville, M E
AU  - Saville ME
FAU - Stock, M J
AU  - Stock MJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 9Y8NXQ24VQ (Propranolol)
RN  - O5CB12L4FN (Diazoxide)
RN  - S88TT14065 (Oxygen)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - *Body Temperature Regulation/drug effects
MH  - Diazoxide/pharmacology
MH  - Diet
MH  - Eating
MH  - Fasting
MH  - Insulin/pharmacology/*physiology
MH  - Male
MH  - Norepinephrine/pharmacology
MH  - Oxygen/blood
MH  - Propranolol/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Rats, Zucker
EDAT- 1983/08/01 00:00
MHDA- 1983/08/01 00:01
CRDT- 1983/08/01 00:00
PHST- 1983/08/01 00:00 [pubmed]
PHST- 1983/08/01 00:01 [medline]
PHST- 1983/08/01 00:00 [entrez]
AID - 10.1152/ajpendo.1983.245.2.E160 [doi]
PST - ppublish
SO  - Am J Physiol. 1983 Aug;245(2):E160-5. doi: 10.1152/ajpendo.1983.245.2.E160.