PMID- 6349389
OWN - NLM
STAT- MEDLINE
DCOM- 19830920
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 245
IP  - 2
DP  - 1983 Aug
TI  - Angiotensin II in the renal excretory response to behavioral stress in conscious 
      dogs.
PG  - R259-64
AB  - The effects of inhibition of the renin-angiotensin system on the decreased renal 
      excretion of sodium and water resulting from behavioral stress (shock avoidance) 
      were examined in conscious saline-infused (4-5 ml/min) dogs. During saline 
      infusion alone in six dogs, avoidance decreased sodium excretion (64% from 329 
      mueq/min) and urine flow (63% from 1.9 ml/min). During converting enzyme 
      inhibition with captopril in the same dogs, the decreases in sodium excretion 
      (35% from 464 mueq/min) and urine flow (35% from 2.6 ml/min) during avoidance 
      were attenuated. Similarly, in six other dogs, avoidance decreased sodium 
      excretion (41% from 361 mueq/min) and urine flow (43% from 2.1 ml/min) with 
      saline infusion alone. During angiotension II (ANG II) receptor antagonism with 
      saralasin, decreases in sodium excretion (29% from 417 mueq/min) and urine flow 
      (27% from 2.2 ml/min) were attenuated. These mean changes in excretion during 
      inhibition of the renin-angiotensin system were significantly (P less than 0.05) 
      less than during saline alone. Whereas decreases in fractional sodium and water 
      excretion were attenuated by renin-angiotensin inhibition, decreases in 
      glomerular filtration rate and effective renal blood flow and increases in mean 
      arterial pressure were not affected. These results indicate that ANG II 
      contributes to the renal excretory response to avoidance.
FAU - Koepke, J P
AU  - Koepke JP
FAU - Obrist, P A
AU  - Obrist PA
LA  - eng
GR  - HL-18976/HL/NHLBI NIH HHS/United States
GR  - HL-23718/HL/NHLBI NIH HHS/United States
GR  - RR-46/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 11128-99-7 (Angiotensin II)
RN  - 9041-90-1 (Angiotensin I)
RN  - 9G64RSX1XD (Captopril)
RN  - 9NEZ333N27 (Sodium)
RN  - H2AFV2HE66 (Saralasin)
SB  - IM
MH  - Angiotensin I/pharmacology
MH  - Angiotensin II/*pharmacology
MH  - Animals
MH  - Avoidance Learning
MH  - Captopril/pharmacology
MH  - Dogs
MH  - Glomerular Filtration Rate/drug effects
MH  - Humans
MH  - Kidney/drug effects/innervation/*physiopathology
MH  - Male
MH  - Renal Circulation/drug effects
MH  - Saralasin/pharmacology
MH  - Sodium/urine
MH  - Stress, Psychological/*physiopathology
EDAT- 1983/08/01 00:00
MHDA- 1983/08/01 00:01
CRDT- 1983/08/01 00:00
PHST- 1983/08/01 00:00 [pubmed]
PHST- 1983/08/01 00:01 [medline]
PHST- 1983/08/01 00:00 [entrez]
AID - 10.1152/ajpregu.1983.245.2.R259 [doi]
PST - ppublish
SO  - Am J Physiol. 1983 Aug;245(2):R259-64. doi: 10.1152/ajpregu.1983.245.2.R259.