PMID- 6353616
OWN - NLM
STAT- MEDLINE
DCOM- 19831123
LR  - 20140912
IS  - 0256-9574 (Print)
VI  - 64
IP  - 14
DP  - 1983 Sep 28
TI  - Further experience with long-term captopril therapy in severe refractory 
      congestive heart failure.
PG  - 510-5
AB  - Fifty patients in severe congestive heart failure (CHF) were treated with 
      captopril (Capoten; Squibb), an oral angiotensin-converting enzyme inhibitor, 
      over a 2-year period (range 3-24 months, mean 8,6 +/- 7,7 months). At entry, all 
      patients were in New York Heart Association (NYHA) functional class IV despite 
      high-dose diuretic and conventional vasodilator therapy. The overall cumulative 
      survival at 6 and 12 months was 64% and 53% respectively. There were 22 deaths 
      (18 during captopril therapy) including 8 sudden deaths. At 2-year follow-up 
      (mean 14,6 +/- 6,9 months), there were 25 survivors on captopril; 18 in NYHA 
      class I or IIS and 7 in class IIM or III. Diuretic requirements were decreased 
      considerably in all. Side-effects were common but transient and in no case did 
      captopril have to be withdrawn. We confirm our earlier conclusion that captopril 
      has long-term beneficial effects and is a highly effective drug in the treatment 
      of patients with CHF refractory to currently accepted therapy. Sudden death 
      despite satisfactory clinical improvement continues to cause concern. Precautions 
      which may reduce or avoid these are briefly discussed.
FAU - King, J
AU  - King J
FAU - Steingo, L
AU  - Steingo L
FAU - Barlow, J B
AU  - Barlow JB
FAU - Jardine, R
AU  - Jardine R
FAU - Goldman, A P
AU  - Goldman AP
FAU - Allman, B
AU  - Allman B
FAU - Pocock, W A
AU  - Pocock WA
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - S Afr Med J
JT  - South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
JID - 0404520
RN  - 9DLQ4CIU6V (Proline)
RN  - 9G64RSX1XD (Captopril)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Captopril/*therapeutic use
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/*drug therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Proline/*analogs & derivatives
EDAT- 1983/09/28 00:00
MHDA- 1983/09/28 00:01
CRDT- 1983/09/28 00:00
PHST- 1983/09/28 00:00 [pubmed]
PHST- 1983/09/28 00:01 [medline]
PHST- 1983/09/28 00:00 [entrez]
PST - ppublish
SO  - S Afr Med J. 1983 Sep 28;64(14):510-5.