PMID- 6364666
OWN - NLM
STAT- MEDLINE
DCOM- 19840302
LR  - 20191031
IS  - 0001-5563 (Print)
IS  - 0001-5563 (Linking)
VI  - 20
IP  - 4
DP  - 1983 Oct-Dec
TI  - The treatment of unstable type I diabetes: conventional versus portable pump 
      insulin administration.
PG  - 363-70
AB  - The treatment of unstable insulin-dependent diabetics (UIDD) is still an unsolved 
      problem. A comparison was made between optimized conventional treatment (OCT) 
      (Ultralente + Actrapid at breakfast, Actrapid at lunch and Actrapid at dinner) 
      and continuous s.c. insulin infusion (CSII) for 30 days in 10 UIDD outpatients. 
      Continuous 24-h blood glucose monitoring with an artificial pancreas, fasting 
      values of HbA1, plasma lipids, growth hormone, glucagon, daily urinary glucose 
      and protein excretion were recorded after each treatment; a daily blood glucose 
      profile was determined every week. Daily mean blood glucose values dropped 
      significantly (p less than 0.01): from 187.2 +/- 66.6 (OCT) to 111.6 +/- 27.0 
      mg/dl (CSII), and hypoglycemic and ketotic events disappeared during CSII. A 
      significant improvement (p less than 0.01 - p less than 0.001) in all other 
      parameters was also observed. It is suggested that CSII may help to improve 
      metabolic control and the quality of life in UIDD.
FAU - Cavallo-Perin, P
AU  - Cavallo-Perin P
FAU - Pagano, G
AU  - Pagano G
FAU - Tagliaferro, V
AU  - Tagliaferro V
FAU - Jarre, P
AU  - Jarre P
FAU - Ozzello, A
AU  - Ozzello A
FAU - Lenti, G
AU  - Lenti G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Italy
TA  - Acta Diabetol Lat
JT  - Acta diabetologica latina
JID - 0123567
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Blood Glucose/analysis
MH  - Diabetes Mellitus, Type 1/*drug therapy/metabolism
MH  - Female
MH  - Humans
MH  - Injections, Subcutaneous/methods
MH  - Insulin/*administration & dosage
MH  - Insulin Infusion Systems
MH  - Male
EDAT- 1983/10/01 00:00
MHDA- 1983/10/01 00:01
CRDT- 1983/10/01 00:00
PHST- 1983/10/01 00:00 [pubmed]
PHST- 1983/10/01 00:01 [medline]
PHST- 1983/10/01 00:00 [entrez]
AID - 10.1007/BF02581168 [doi]
PST - ppublish
SO  - Acta Diabetol Lat. 1983 Oct-Dec;20(4):363-70. doi: 10.1007/BF02581168.