PMID- 6368506
OWN - NLM
STAT- MEDLINE
DCOM- 19840521
LR  - 20191031
IS  - 0197-0070 (Print)
IS  - 0197-0070 (Linking)
VI  - 5
IP  - 2
DP  - 1984 Apr
TI  - Intranasal administration of RA 27/3 rubella virus vaccine. A clinical trial in 
      young adults.
PG  - 75-8
AB  - Of the vaccines and inoculation routes studied for the prevention of rubella, 
      only the RA27/3 vaccine, administered intranasally, has the ability to stimulate 
      a humoral antibody pattern very similar to that evoked by wild rubella infection. 
      Because information about intranasal (IN) vaccination has only been obtained 
      using the RA 27/3 vaccine manufactured in Europe, we conducted a trial of IN 
      vaccination among young adults using Meruvax II which is manufactured in the USA. 
      Of 597 family planning clinic patients screened in 1980-1981, 71 (11.9%) were 
      susceptible to rubella; forty-one subjects were randomly assigned to receive IN 
      or subcutaneous (SC) vaccine. All 20 SC vaccinees, but only 8/21 (38%) IN 
      vaccinees, were successfully immunized. We conclude that standard doses of 
      commercially available RA 27/3 vaccine are insufficient for IN immunization 
      against rubella. Additional study of the dose-response relationship is needed if 
      IN vaccination is to be recommended.
FAU - Paradise, J E
AU  - Paradise JE
FAU - Nemorofsky, D
AU  - Nemorofsky D
FAU - Huggins, G R
AU  - Huggins GR
FAU - Sondheimer, S J
AU  - Sondheimer SJ
FAU - Plotkin, S A
AU  - Plotkin SA
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Adolesc Health Care
JT  - Journal of adolescent health care : official publication of the Society for 
      Adolescent Medicine
JID - 8100395
RN  - 0 (Antibodies, Viral)
RN  - 0 (Rubella Vaccine)
SB  - IM
MH  - Administration, Intranasal
MH  - Adolescent
MH  - Adult
MH  - Antibodies, Viral/analysis
MH  - Clinical Trials as Topic
MH  - Female
MH  - Humans
MH  - Injections, Subcutaneous
MH  - Random Allocation
MH  - Rubella/immunology/*prevention & control
MH  - Rubella Vaccine/*administration & dosage/adverse effects
EDAT- 1984/04/01 00:00
MHDA- 1984/04/01 00:01
CRDT- 1984/04/01 00:00
PHST- 1984/04/01 00:00 [pubmed]
PHST- 1984/04/01 00:01 [medline]
PHST- 1984/04/01 00:00 [entrez]
AID - 10.1016/s0197-0070(84)80002-9 [doi]
PST - ppublish
SO  - J Adolesc Health Care. 1984 Apr;5(2):75-8. doi: 10.1016/s0197-0070(84)80002-9.