PMID- 6369973
OWN - NLM
STAT- MEDLINE
DCOM- 19840504
LR  - 20190627
IS  - 0002-9343 (Print)
IS  - 0002-9343 (Linking)
VI  - 76
IP  - 3A
DP  - 1984 Mar 30
TI  - Significance of immunoglobulin G subclasses.
PG  - 1-6
AB  - IgG subclasses differ from one another both immunochemically and functionally. An 
      isolated absence of a certain specific subclass may or may not be associated with 
      disease. However, an absence of serum IgG4 as measured by a sensitive 
      radioimmunoassay is usually, if not always, associated with severe recurrent 
      pyogenic infections, usually of the respiratory tract. IgG2 and IgG4 deficiencies 
      tends to occur together, often in association with deficiencies of immunoglobulin 
      A (IgA) and/or immunoglobulin E (IgE). The properties of IgG1 are similar to 
      those of IgG3 and those of IgG2 appear to resemble those of IgG4 in certain 
      respects. Specific combined deficiencies tend to be associated with certain 
      diseases. Some patients with deficiency of an immunoglobulin G (IgG) subclass 
      appear able to compensate and to avoid clinical disease whereas others are not. 
      Overlap zones exist in the lower ranges of serum concentrations in which both 
      healthy and immunoincompetent subjects are found. It is important to consider the 
      concentration of each IgG subclass present in a gamma globulin preparation or in 
      plasma used for replacement therapy. If specific antibody deficiencies exist, it 
      may be critical that the preparation used for replacement contains goodly amounts 
      of the missing antibodies.
FAU - Heiner, D C
AU  - Heiner DC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Am J Med
JT  - The American journal of medicine
JID - 0267200
RN  - 0 (Diphtheria Toxoid)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Polysaccharides, Bacterial)
RN  - 0 (Receptors, Antigen)
RN  - 0 (Tetanus Toxoid)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Ataxia Telangiectasia/immunology
MH  - Bacterial Infections/etiology/immunology
MH  - Child
MH  - Desensitization, Immunologic
MH  - Diphtheria Toxoid/administration & dosage
MH  - Dysgammaglobulinemia/complications/genetics/*immunology
MH  - Female
MH  - Humans
MH  - Hypersensitivity/immunology
MH  - IgA Deficiency
MH  - *IgG Deficiency
MH  - Immunoglobulin E/biosynthesis
MH  - Immunoglobulin G/analysis/biosynthesis
MH  - Infectious Mononucleosis/immunology
MH  - Male
MH  - Middle Aged
MH  - Polysaccharides, Bacterial/immunology
MH  - Receptors, Antigen
MH  - Tetanus Toxoid/administration & dosage
RF  - 60
EDAT- 1984/03/30 00:00
MHDA- 1984/03/30 00:01
CRDT- 1984/03/30 00:00
PHST- 1984/03/30 00:00 [pubmed]
PHST- 1984/03/30 00:01 [medline]
PHST- 1984/03/30 00:00 [entrez]
AID - 0002-9343(84)90313-9 [pii]
AID - 10.1016/0002-9343(84)90313-9 [doi]
PST - ppublish
SO  - Am J Med. 1984 Mar 30;76(3A):1-6. doi: 10.1016/0002-9343(84)90313-9.