PMID- 6375212
OWN - NLM
STAT- MEDLINE
DCOM- 19840709
LR  - 20090608
IS  - 0176-6724 (Print)
IS  - 0176-6724 (Linking)
VI  - 256
IP  - 3
DP  - 1984 Mar
TI  - Action of a new floxacrine derivative (S 82 5455) on asexual stages of Plasmodium 
      berghei: a light and electron microscopical study.
PG  - 335-41
AB  - The floxacrine derivative S 82 5455, 7-chloro-1-( 4N - methylpiperazino 
      -1N-imino)-10-hydroxy-1, 2, 3, 4-tetrahydro-3-(4-trifluoromethylphenyl)-9(10 H)- 
      acridone , shows a high activity against blood induced infection of a 
      drug-sensitive line of Plasmodium berghei in mice and rats. The dosis curativa 
      minima/ dosis tolerata maxima values against the drug-sensitive P. berghei strain 
      ascertained in the '28-day test' in mice, were 1.56 (X 5)/400 (X 1) mg/kg after 
      the oral route 3.12(X 5)/400(X 1) mg/kg after the subcutaneous (sc) route. 
      Morphological changes in erythrocytic stages of P. berghei following a single 
      oral/sc dose of 25 and 50 mg/kg respectively in rats were at first swollen 
      lacunes of the endoplasmic reticulum and extremely enlarged mitochondrion (6 h 
      after treatment), then an apparent vacuolisation of the cytoplasm and pyknosis of 
      the nucleus, as well as distinctly enlarged perinuclear space and later marked 
      fissuring of the cytoplasm. After 23 h most of the parasites were destroyed by 
      disruption of their pellicle. The majority of the degenerate parasites were 
      situated outside of the apparently ruptured host cell. The remnants of damaged 
      parasites and host cells disappeared completely from smears 96 h after treatment 
      at all oral and sc doses used.
FAU - Raether, W
AU  - Raether W
FAU - Mehlhorn, H
AU  - Mehlhorn H
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Zentralbl Bakteriol Mikrobiol Hyg A
JT  - Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical 
      microbiology, infectious diseases, virology, parasitology
JID - 8403032
RN  - 0 (Acridines)
RN  - 0 (Antiprotozoal Agents)
RN  - 90832-34-1 (S 82-5455)
SB  - IM
MH  - Acridines/administration & dosage/*pharmacology
MH  - Animals
MH  - Antiprotozoal Agents/administration & dosage/*pharmacology/therapeutic use
MH  - Blood/parasitology
MH  - Chemical Phenomena
MH  - Chemistry
MH  - Female
MH  - Malaria/drug therapy/*parasitology
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Microscopy, Electron
MH  - Plasmodium berghei/*drug effects/ultrastructure
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1984/03/01 00:00
MHDA- 1984/03/01 00:01
CRDT- 1984/03/01 00:00
PHST- 1984/03/01 00:00 [pubmed]
PHST- 1984/03/01 00:01 [medline]
PHST- 1984/03/01 00:00 [entrez]
PST - ppublish
SO  - Zentralbl Bakteriol Mikrobiol Hyg A. 1984 Mar;256(3):335-41.