PMID- 6377512
OWN - NLM
STAT- MEDLINE
DCOM- 19840822
LR  - 20061115
IS  - 0125-1562 (Print)
IS  - 0125-1562 (Linking)
VI  - 15
IP  - 1
DP  - 1984 Mar
TI  - HLA antigens and malaria at San Lazaro Hospital Manila, Philippines.
PG  - 1-6
AB  - Human leucocyte antigens (HLA) were used as genetic markers in an attempt to 
      determine possible host genetic susceptibility or resistance to malarial 
      infections. HLA-A and B typing on lymphocytes from 68 confirmed P. falciparum and 
      77 P. vivax cases was compared with that found in 66 control subjects with no 
      known history of malaria. A significant deviation was observed in the 
      distribution of HLA-B27. This phenotype was absent in the P. falciparum group 
      although found present in the P. vivax group (10%) and the control group (11%). 
      Also, the combination of A9(w24) and B5 was significantly higher among the P. 
      falciparum group than that found in the P. vivax and control groups. These 
      findings require confirmation but do suggest the possibility of genetic 
      susceptibility and that extensive genetic studies might be worth investigating.
FAU - Sy, N E
AU  - Sy NE
FAU - Long, G W
AU  - Long GW
FAU - Alcantara, A K
AU  - Alcantara AK
FAU - Ranoa, C P
AU  - Ranoa CP
FAU - Cross, J H
AU  - Cross JH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - Thailand
TA  - Southeast Asian J Trop Med Public Health
JT  - The Southeast Asian journal of tropical medicine and public health
JID - 0266303
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
SB  - IM
MH  - Disease Susceptibility
MH  - Female
MH  - *HLA Antigens/analysis
MH  - HLA-A Antigens
MH  - HLA-B Antigens
MH  - Humans
MH  - Malaria/genetics/*immunology
MH  - Male
MH  - Philippines
MH  - Plasmodium falciparum/immunology
MH  - Plasmodium vivax/immunology
EDAT- 1984/03/01 00:00
MHDA- 1984/03/01 00:01
CRDT- 1984/03/01 00:00
PHST- 1984/03/01 00:00 [pubmed]
PHST- 1984/03/01 00:01 [medline]
PHST- 1984/03/01 00:00 [entrez]
PST - ppublish
SO  - Southeast Asian J Trop Med Public Health. 1984 Mar;15(1):1-6.