PMID- 6378788
OWN - NLM
STAT- MEDLINE
DCOM- 19840914
LR  - 20190722
IS  - 0194-911X (Print)
IS  - 0194-911X (Linking)
VI  - 6
IP  - 4
DP  - 1984 Jul-Aug
TI  - Pressor hyperresponsiveness in saline-infused rabbits.
PG  - 503-10
AB  - Conscious rabbits infused intravenously (i.v.) with isotonic saline at 1.5 to 1.8 
      ml/min for 24 hours had greater pressor responses to norepinephrine (NE) than did 
      normal control rabbits. Infusion of the angiotension II (ANG II) antagonist 
      [Sar1, Ile8] ANG II did not decrease the exaggerated pressor responses to NE in 
      saline-infused rabbits. Measurements of cardiac output (CO) as well as the 
      pressor responses to NE before and after saline infusion revealed that, although 
      saline infusion increased the CO and decreased total peripheral resistance (TPR), 
      CO did not change during NE infusion either before or after saline infusion, but 
      NE produced significantly greater increases in mean arterial pressure (MAP) and 
      TPR after saline infusion than before the saline infusion. The cross-circulation 
      of blood at 10 ml/min for 5 minutes between saline-infused donor rabbits and 
      normal recipient rabbits resulted in pressor hyperresponsiveness to NE in the 
      normal recipients. Similar cross-circulation experiments between pairs of normal 
      rabbits did not alter the pressor responses to NE. These studies provided direct 
      evidence that expansion of body fluid volumes by saline infusion results in 
      pressor and vascular hyperresponsiveness. There was no evidence to indicate that 
      ANG II was involved in the mechanisms producing this pressor hyperresponsiveness. 
      Some circulating hormonal factor, however, was involved in mediating the pressor 
      hyperresponsiveness following saline infusion. The results of this study are 
      compatible with the concept that natriuretic hormone may play a role in promoting 
      pressor hyperresponsiveness in saline-expanded animals.
FAU - Sakamaki, T
AU  - Sakamaki T
FAU - Johnson, J A
AU  - Johnson JA
FAU - Zeigler, D W
AU  - Zeigler DW
FAU - Koivunen, D G
AU  - Koivunen DG
FAU - Siripaisarnpipat, S
AU  - Siripaisarnpipat S
FAU - Fowler, W L Jr
AU  - Fowler WL Jr
FAU - Payne, C G
AU  - Payne CG
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Hypertension
JT  - Hypertension (Dallas, Tex. : 1979)
JID - 7906255
RN  - 11128-99-7 (Angiotensin II)
RN  - 451W47IQ8X (Sodium Chloride)
RN  - 9NEZ333N27 (Sodium)
RN  - EC 3.4.23.15 (Renin)
RN  - RWP5GA015D (Potassium)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Angiotensin II/antagonists & inhibitors
MH  - Animals
MH  - Blood Pressure/*drug effects
MH  - Capillaries
MH  - Cross Circulation
MH  - Heart Rate/drug effects
MH  - Infusions, Parenteral
MH  - Male
MH  - Norepinephrine/pharmacology
MH  - Potassium/blood
MH  - Rabbits
MH  - Renin/blood
MH  - Sodium/blood/metabolism
MH  - Sodium Chloride/*pharmacology
MH  - Vascular Resistance/drug effects
EDAT- 1984/07/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1984/07/01 00:00
PHST- 1984/07/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1984/07/01 00:00 [entrez]
AID - 10.1161/01.hyp.6.4.503 [doi]
PST - ppublish
SO  - Hypertension. 1984 Jul-Aug;6(4):503-10. doi: 10.1161/01.hyp.6.4.503.