PMID- 6381959
OWN - NLM
STAT- MEDLINE
DCOM- 19841002
LR  - 20190725
IS  - 0026-0495 (Print)
IS  - 0026-0495 (Linking)
VI  - 33
IP  - 9
DP  - 1984 Sep
TI  - Comparative study of isomalt and sucrose by means of continuous indirect 
      calorimetry.
PG  - 808-13
AB  - Isomalt (Palatinit) an equimolar mixture of alpha-D-glucopyranosido-1,6-sorbitol 
      and alpha-D-glucopyranosido-1,6-mannitol, was compared to sucrose in a 
      prospective double-blind controlled crossover study. The acute effects of oral 
      ingestion of 30-g loads of isomalt or sucrose on plasma glucose, insulin, free 
      fatty acids (FFA), lactic acid, and carbohydrate (CHO) and lipid oxidation were 
      studied over six hours by means of continuous indirect calorimetry in ten healthy 
      normal-weight subjects. Unlike sucrose, whose ingestion was followed by 
      significant changes in plasma glucose, insulin, and lactic acid during the first 
      60 minutes of the test, no significant changes in these parameters were observed 
      following the administration of isomalt. The increase in CHO oxidation occurring 
      between 30 and 150 minutes was significantly lower (P less than 0.01) following 
      isomalt than after sucrose. Conversely, the decrease in lipid oxidation was 
      significantly less (P less than 0.01) after isomalt in comparison to sucrose. It 
      is concluded that the rise in CHO oxidation and in plasma glucose and insulin 
      levels is markedly reduced when sucrose is replaced by an equal weight of 
      isomalt. In contrast to other sugar substitutes, no increase in plasma lactic 
      acid was observed after isomalt administration.
FAU - Thiebaud, D
AU  - Thiebaud D
FAU - Jacot, E
AU  - Jacot E
FAU - Schmitz, H
AU  - Schmitz H
FAU - Spengler, M
AU  - Spengler M
FAU - Felber, J P
AU  - Felber JP
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Blood Glucose)
RN  - 0 (Disaccharides)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Insulin)
RN  - 0 (Lactates)
RN  - 0 (Sugar Alcohols)
RN  - 0 (Sweetening Agents)
RN  - 57-50-1 (Sucrose)
RN  - 64519-82-0 (Palatinit)
SB  - IM
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Calorimetry/methods
MH  - Carbohydrate Metabolism
MH  - Disaccharides/*metabolism
MH  - Double-Blind Method
MH  - Energy Metabolism
MH  - Fatty Acids, Nonesterified/blood
MH  - Humans
MH  - Insulin/blood
MH  - Lactates/blood
MH  - Lipid Metabolism
MH  - Male
MH  - Oxidation-Reduction
MH  - Random Allocation
MH  - Sucrose/*metabolism
MH  - Sugar Alcohols/*metabolism
MH  - Sweetening Agents/*metabolism
EDAT- 1984/09/01 00:00
MHDA- 1984/09/01 00:01
CRDT- 1984/09/01 00:00
PHST- 1984/09/01 00:00 [pubmed]
PHST- 1984/09/01 00:01 [medline]
PHST- 1984/09/01 00:00 [entrez]
AID - 0026-0495(84)90106-9 [pii]
AID - 10.1016/0026-0495(84)90106-9 [doi]
PST - ppublish
SO  - Metabolism. 1984 Sep;33(9):808-13. doi: 10.1016/0026-0495(84)90106-9.