PMID- 6384294
OWN - NLM
STAT- MEDLINE
DCOM- 19841101
LR  - 20201214
IS  - 0190-9622 (Print)
IS  - 0190-9622 (Linking)
VI  - 11
IP  - 3
DP  - 1984 Sep
TI  - Relationships between antinuclear and anti-Ro/SS-A antibodies in subacute 
      cutaneous lupus erythematosus.
PG  - 494-9
AB  - A certain degree of confusion has arisen regarding the relationship between 
      patients having subacute cutaneous lupus erythematosus (SCLE) and those with 
      "antinuclear antibody-negative" systemic lupus erythematosus (ANA-negative SLE). 
      One of the confusing issues relates to published differences in the autoimmune 
      serologic findings of these two patient groups. In order to clarify this issue, 
      we have screened the sera from thirty-seven patients with SCLE for the presence 
      of fluorescent antinuclear antibodies (FANA) on two different substrates--human 
      Hep-2 tissue culture cells and mouse kidney sections. In addition, these same 
      sera were assayed for anti-Ro/SS-A precipitin antibodies. Seventy-eight percent 
      of the sera were FANA-positive at a titer of 1:10 or greater when tested on human 
      Hep-2 cells, whereas 76% were positive at a titer of 1:80 or greater. Fifty-one 
      percent were positive on mouse kidney sections at a titer of 1:10 or greater, 
      whereas 46% were positive at a titer of 1:20 or greater. Twenty-two percent of 
      these sera were completely FANA-negative on both human and mouse substrates. None 
      of these sera that were negative on both substrates contained anti-Ro/SS-A 
      antibodies. However, 69% of the sera that were FANA-positive on both human and 
      mouse substrates were found to have detectable anti-Ro/SS-A antibodies. Ninety 
      percent of the SCLE sera that were FANA-positive on human Hep-2 cells, but 
      negative on mouse kidney sections, contained anti-Ro/SS-A antibodies. These sera 
      gave a speckle-like, or particulate, nuclear immunofluorescence staining 
      pattern.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Deng, J S
AU  - Deng JS
FAU - Sontheimer, R D
AU  - Sontheimer RD
FAU - Gilliam, J N
AU  - Gilliam JN
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Am Acad Dermatol
JT  - Journal of the American Academy of Dermatology
JID - 7907132
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Antigens)
RN  - 0 (Autoantibodies)
RN  - 0 (Autoantigens)
RN  - 0 (Precipitins)
RN  - 0 (RNA, Small Cytoplasmic)
RN  - 0 (RO60 protein, human)
RN  - 0 (Ribonucleoproteins)
RN  - 0 (SS-A antigen)
SB  - IM
MH  - Acute Disease
MH  - Animals
MH  - Antibodies, Antinuclear/immunology/*isolation & purification
MH  - Antigens/*immunology
MH  - Autoantibodies/immunology/*isolation & purification
MH  - *Autoantigens
MH  - Autoimmune Diseases/*diagnosis
MH  - Fluorescent Antibody Technique
MH  - Humans
MH  - In Vitro Techniques
MH  - Kidney
MH  - Lupus Erythematosus, Discoid/*diagnosis/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Precipitins/immunology/*isolation & purification
MH  - *RNA, Small Cytoplasmic
MH  - *Ribonucleoproteins
EDAT- 1984/09/01 00:00
MHDA- 1984/09/01 00:01
CRDT- 1984/09/01 00:00
PHST- 1984/09/01 00:00 [pubmed]
PHST- 1984/09/01 00:01 [medline]
PHST- 1984/09/01 00:00 [entrez]
AID - S0190-9622(84)70198-8 [pii]
AID - 10.1016/s0190-9622(84)70198-8 [doi]
PST - ppublish
SO  - J Am Acad Dermatol. 1984 Sep;11(3):494-9. doi: 10.1016/s0190-9622(84)70198-8.