PMID- 6388580
OWN - NLM
STAT- MEDLINE
DCOM- 19841205
LR  - 20190623
IS  - 0006-2952 (Print)
IS  - 0006-2952 (Linking)
VI  - 33
IP  - 21
DP  - 1984 Nov 1
TI  - Effect of chronic phenobarbital treatment on folates and one-carbon enzymes in 
      the rat.
PG  - 3457-63
AB  - Chronic oral phenobarbital treatment (50 mg/kg every 12 hr for 8 weeks), which 
      was nontoxic and continuously protective against seizures in rats, significantly 
      decreased folate concentration in liver (29%) but not in brain or plasma. The 
      apparent activity of 5,10-methylenetetrahydrofolate reductase (MTR) in liver 
      decreased with initiation of treatment but then increased with a significant 
      correlation to the length of treatment. Phenobarbital also stimulated the 
      activity of this enzyme slightly in vitro. Methionine adenosyltransferase (MAT) 
      activity was inhibited by high concentrations of phenobarbital in vitro but was 
      not affected in vivo. No significant effects of phenobarbital on the activities 
      of serine hydroxymethyltransferase (SHMT) or 
      5-methyltetrahydrofolate:homocysteine methyltransferase (MHMT) were observed 
      either in vivo or in vitro.
FAU - Carl, G F
AU  - Carl GF
FAU - Smith, D B
AU  - Smith DB
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - Biochem Pharmacol
JT  - Biochemical pharmacology
JID - 0101032
RN  - 935E97BOY8 (Folic Acid)
RN  - EC 1.1.- (Alcohol Oxidoreductases)
RN  - EC 1.5.1.20 (5,10-Methylenetetrahydrofolate Reductase (FADH2))
RN  - EC 2.- (Transferases)
RN  - EC 2.1.1.- (Methyltransferases)
RN  - EC 2.1.1.13 (5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase)
RN  - EC 2.1.2.1 (Glycine Hydroxymethyltransferase)
RN  - EC 2.5.1.6 (Methionine Adenosyltransferase)
RN  - YQE403BP4D (Phenobarbital)
SB  - IM
MH  - 5,10-Methylenetetrahydrofolate Reductase (FADH2)
MH  - 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase/*analysis
MH  - Alcohol Oxidoreductases/*analysis
MH  - Animals
MH  - Brain/enzymology
MH  - Folic Acid/*analysis
MH  - Glycine Hydroxymethyltransferase/*analysis
MH  - Liver/enzymology
MH  - Male
MH  - Methionine Adenosyltransferase/*analysis
MH  - Methyltransferases/*analysis
MH  - Phenobarbital/*pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Transferases/*analysis
EDAT- 1984/11/01 00:00
MHDA- 1984/11/01 00:01
CRDT- 1984/11/01 00:00
PHST- 1984/11/01 00:00 [pubmed]
PHST- 1984/11/01 00:01 [medline]
PHST- 1984/11/01 00:00 [entrez]
AID - 0006-2952(84)90120-5 [pii]
AID - 10.1016/0006-2952(84)90120-5 [doi]
PST - ppublish
SO  - Biochem Pharmacol. 1984 Nov 1;33(21):3457-63. doi: 10.1016/0006-2952(84)90120-5.