PMID- 6388815
OWN - NLM
STAT- MEDLINE
DCOM- 19841228
LR  - 20191210
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 54
IP  - 11 Suppl
DP  - 1984 Dec 1
TI  - Bone marrow transplantation in leukemia. Current status.
PG  - 2732-40
AB  - Intensive cytoreductive therapy may be curative in certain hematopoietic 
      malignancies, but its administration is limited by lethal marrow toxicity. Bone 
      marrow transplantation (BMT) provides a way of rescue from this toxicity. The 
      donor may be a human leukocyte antigen (HLA) "matched" sibling (allogeneic), an 
      identical twin (syngeneic), or the patient (autologous). Long remissions and 
      possible cures of 50% to 60% have been reported in acute leukemia after intensive 
      treatment with chemotherapy, with and without total body irradiation, followed by 
      allogeneic BMT. A similar approach has been used in chronic myelocytic leukemia 
      (CML) and in non-Hodgkin's lymphoma with encouraging results. Results are best in 
      younger patients and those transplanted early in their disease (i.e., in the 
      first remission for acute leukemia and in the chronic phase of the disease in 
      CML). Solutions to major problems associated with allogeneic BMT, such as 
      graft-versus-host disease and viral infections, are being actively pursued. 
      Syngeneic BMT avoids some of the above problems, but relapses appear to be 
      greater. Nevertheless, this approach has produced a significant number of cures. 
      Autologous BMT is the newest approach, and the demonstration that marrow may be 
      purged of residual tumor cells by immunologic or pharmacologic means has 
      engendered enthusiasm for this area of clinical therapeutic investigation.
FAU - Santos, G W
AU  - Santos GW
LA  - eng
GR  - CA-15396/CA/NCI NIH HHS/United States
GR  - CAO-06973/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
SB  - IM
MH  - *Bone Marrow Transplantation
MH  - Graft vs Host Disease/therapy
MH  - Humans
MH  - Infections/etiology
MH  - Leukemia/*therapy
MH  - Leukemia, Lymphoid/therapy
MH  - Leukemia, Myeloid/therapy
MH  - Pulmonary Fibrosis/etiology
MH  - Transplantation, Autologous
MH  - Whole-Body Irradiation
RF  - 81
EDAT- 1984/12/01 00:00
MHDA- 1984/12/01 00:01
CRDT- 1984/12/01 00:00
PHST- 1984/12/01 00:00 [pubmed]
PHST- 1984/12/01 00:01 [medline]
PHST- 1984/12/01 00:00 [entrez]
AID - 10.1002/1097-0142(19841201)54:2+<2732::aid-cncr2820541421>3.0.co;2-a [doi]
PST - ppublish
SO  - Cancer. 1984 Dec 1;54(11 Suppl):2732-40. doi: 
      10.1002/1097-0142(19841201)54:2+<2732::aid-cncr2820541421>3.0.co;2-a.