PMID- 6395048
OWN - NLM
STAT- MEDLINE
DCOM- 19850320
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 52
IP  - 3
DP  - 1984 Dec 21
TI  - A role for taurine in the maintenance of homeostasis in the central nervous 
      system during hyperexcitation?
PG  - 341-6
AB  - Employing the brain dialysis technique, we demonstrate that the aspartate 
      congener N-methyl-D,L-aspartic acid (NMA) stimulates the release of endogenous 
      taurine in vivo in a Ca2+-dependent manner. Furthermore, exogenous taurine (1-10 
      mM) inhibits the NMA-induced Ca2+ influx into intracellular compartments. This 
      suggests that the extracellular taurine concentration may control Ca2+ movement 
      and thereby provide a homeostatic mechanism in situations of excessive 
      excitation.
FAU - Lehmann, A
AU  - Lehmann A
FAU - Hagberg, H
AU  - Hagberg H
FAU - Hamberger, A
AU  - Hamberger A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 1EQV5MLY3D (Taurine)
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Aspartic Acid/*analogs & derivatives/pharmacology
MH  - Calcium/*metabolism
MH  - Cell Membrane Permeability/drug effects
MH  - Hippocampus/*metabolism
MH  - Homeostasis
MH  - N-Methylaspartate
MH  - Rabbits
MH  - Taurine/*metabolism
EDAT- 1984/12/21 00:00
MHDA- 1984/12/21 00:01
CRDT- 1984/12/21 00:00
PHST- 1984/12/21 00:00 [pubmed]
PHST- 1984/12/21 00:01 [medline]
PHST- 1984/12/21 00:00 [entrez]
AID - 0304-3940(84)90185-X [pii]
AID - 10.1016/0304-3940(84)90185-x [doi]
PST - ppublish
SO  - Neurosci Lett. 1984 Dec 21;52(3):341-6. doi: 10.1016/0304-3940(84)90185-x.