PMID- 6395196
OWN - NLM
STAT- MEDLINE
DCOM- 19850227
LR  - 20190825
IS  - 0090-6980 (Print)
IS  - 0090-6980 (Linking)
VI  - 28
IP  - 4
DP  - 1984 Oct
TI  - Comparison of gastric and intestinal antisecretory and protective effects of 
      prostacyclin and its stable thia-imino-analogue (Hoe 892) in conscious rats.
PG  - 443-53
AB  - The effects of prostacyclin (PGI2) and its stable thia-thimo-analogue (Hoe 892) 
      on gastric and intestinal secretions and gastric mucosal lesions have been 
      determined in conscious rats. Both PGI2 and Hoe 892 given subcutaneously (s.c.) 
      reduced dose-dependent gastric acid secretion, the ID50 (dose producing 50% 
      inhibition) being about 48.6 and 11.8 micrograms/kg, respectively. In contrast, 
      intragastric (i.g.) PGI2 and Hoe 892 did not cause any change in gastric acid 
      secretion at doses ranging from 1 to 100 micrograms/kg. Both PGI2 and Hoe 892 
      reduced significantly intestinal fluid secretion (antienteropooling activity). 
      PGI2 and Hoe 892 given i.g. or s.c. reduced dose-dependent gastric ulcer 
      formation induced by acidified aspirin (ASA), Hoe 892 being somewhat less potent 
      than PGI2. Both PGI2 and Hoe 892 were equally effective against gastric mucosal 
      necrosis induced by absolute ethanol and this effect was observed both after i.g. 
      and s.c. administration of these agents. We conclude that stable thia-imino-PGI2 
      analogue, Hoe 892, has similar gastric and intestinal antisecretory and 
      protective activity as PGI2 and may be useful in the prevention of gastric damage 
      by various noxious agents.
FAU - Konturek, S J
AU  - Konturek SJ
FAU - Brzozowski, T
AU  - Brzozowski T
FAU - Radecki, T
AU  - Radecki T
FAU - Pastucki, I
AU  - Pastucki I
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Prostaglandins
JT  - Prostaglandins
JID - 0320271
RN  - 75111-35-2 (HOE 892)
RN  - DCR9Z582X0 (Epoprostenol)
RN  - M790V82VAC (16,16-Dimethylprostaglandin E2)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - 16,16-Dimethylprostaglandin E2/pharmacology
MH  - Animals
MH  - Aspirin
MH  - Epoprostenol/*pharmacology
MH  - Gastric Acid/metabolism
MH  - Gastric Mucosa/drug effects/*metabolism
MH  - Intestinal Mucosa/*metabolism
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Stomach Ulcer/chemically induced
EDAT- 1984/10/01 00:00
MHDA- 1984/10/01 00:01
CRDT- 1984/10/01 00:00
PHST- 1984/10/01 00:00 [pubmed]
PHST- 1984/10/01 00:01 [medline]
PHST- 1984/10/01 00:00 [entrez]
AID - 0090-6980(84)90233-8 [pii]
AID - 10.1016/0090-6980(84)90233-8 [doi]
PST - ppublish
SO  - Prostaglandins. 1984 Oct;28(4):443-53. doi: 10.1016/0090-6980(84)90233-8.