PMID- 6400713
OWN - NLM
STAT- MEDLINE
DCOM- 19890327
LR  - 20220409
IS  - 0149-5992 (Print)
IS  - 0149-5992 (Linking)
VI  - 6
IP  - 5
DP  - 1983 Sep-Oct
TI  - Diabetes mellitus and thyroid disease.
PG  - 512-20
AB  - Diabetes mellitus not infrequently coexists with hypo- and hyperthyroidism. 
      Hyperthyroidism aggravates glucose intolerance. A review of this phenomenon 
      reveals multiple mechanisms, which include increased hexose intestinal 
      absorption, decreased responsiveness to insulin, and increased glucose 
      production. Conflicting results are obtained when circulating insulin level is 
      measured in thyrotoxicosis. The role of glucagon and alpha-cell sensitivity is 
      unclear. Diabetes mellitus influences the assessment of thyrotoxicosis by falsely 
      decreasing the blood levels of thyroxine (T4) and triiodothyronine (T3) during 
      severely uncontrolled hyperglycemia. Hypothyroidism is found in about 3% of 
      patients with insulin-dependent diabetes mellitus (IDDM). Moreover, 13-20% of 
      IDDM patients have elevated blood thyrotropin levels and anti-thyroid antibodies. 
      Hypothyroidism per se seems to ameliorate hyperglycemia. A subtype of IDDM shares 
      similar immunogenetic features with familial autoimmune thyroiditis. Studies of 
      IDDM probands who show a high prevalence of circulating thyroid antibodies reveal 
      the presence of such antibodies in their first-degree relatives. Circulating 
      islet-cell antibodies, detected in a majority of IDDM patients at the onset of 
      their disease, tend to persist only in those patients with coexistent 
      polyendocrine autoimmune disease, including thyroiditis. Similar human leukocyte 
      antigen (HLA) locus types are associated with thyroiditis and IDDM, namely 
      HLA-Dr3 and -Dr4.
FAU - Mouradian, M
AU  - Mouradian M
AD  - Division of Endocrinology and Metabolism, American University of Beirut Medical 
      Center, Lebanon.
FAU - Abourizk, N
AU  - Abourizk N
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
RN  - 0 (Thyroid Hormones)
SB  - IM
MH  - *Diabetes Complications
MH  - Diabetes Mellitus/blood
MH  - Humans
MH  - Hyperthyroidism/complications
MH  - Hypothyroidism/complications
MH  - Thyroid Diseases/blood/*complications
MH  - Thyroid Hormones/blood
RF  - 139
EDAT- 1983/09/01 00:00
MHDA- 1983/09/01 00:01
CRDT- 1983/09/01 00:00
PHST- 1983/09/01 00:00 [pubmed]
PHST- 1983/09/01 00:01 [medline]
PHST- 1983/09/01 00:00 [entrez]
AID - 10.2337/diacare.6.5.512 [doi]
PST - ppublish
SO  - Diabetes Care. 1983 Sep-Oct;6(5):512-20. doi: 10.2337/diacare.6.5.512.