PMID- 6401245
OWN - NLM
STAT- MEDLINE
DCOM- 19830225
LR  - 20131121
IS  - 0013-7227 (Print)
IS  - 0013-7227 (Linking)
VI  - 112
IP  - 2
DP  - 1983 Feb
TI  - Evidence of a thyrotropin-releasing hormone-dependent increase in plasma 
      thyrotropin during refeeding of starved rats.
PG  - 715-9
AB  - After 3 days of starvation, refeeding with carbohydrate (CHO) leads to a rapid 
      increase in plasma T4 and T3, suggesting increased TSH secretion. The aim of the 
      present study was to describe the time course of plasma TSH changes during 
      refeeding with CHO and fat. Repetitive blood samples were obtained from freely 
      moving animals by indwelling jugular venous catheters. Refeeding was performed on 
      the fourth day of starvation at either 1100 or 1900 h, and blood was sampled 
      during the preceding hour and during the following 3 h. In control experiments, 
      blood was sampled over 4 h without refeeding. Refeeding with CHO and fat induced 
      a significant increase in plasma TSH in the first hour. This increase could be 
      abolished by a previous injection of an anti-TRH serum, while normal rabbit serum 
      was without effect. Plasma corticosterone, measured hourly, also showed a 
      tendency to increase with refeeding. It is concluded that refeeding of starved 
      rats represents a reproducible stimulus for TSH secretion.
FAU - Hugues, J N
AU  - Hugues JN
FAU - Burger, A G
AU  - Burger AG
FAU - Grouselle, D
AU  - Grouselle D
FAU - Voirol, M J
AU  - Voirol MJ
FAU - Chabert, P
AU  - Chabert P
FAU - Modigliani, E
AU  - Modigliani E
FAU - Sebaoun, J
AU  - Sebaoun J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Endocrinology
JT  - Endocrinology
JID - 0375040
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 5Y5F15120W (Thyrotropin-Releasing Hormone)
RN  - 9002-71-5 (Thyrotropin)
RN  - Q51BO43MG4 (Thyroxine)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Corticosterone/blood
MH  - Dietary Carbohydrates/pharmacology
MH  - Dietary Fats/pharmacology
MH  - *Food
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Starvation/*blood
MH  - Thyrotropin/*blood
MH  - Thyrotropin-Releasing Hormone/*pharmacology
MH  - Thyroxine/blood
MH  - Time Factors
MH  - Triiodothyronine/blood
EDAT- 1983/02/01 00:00
MHDA- 1983/02/01 00:01
CRDT- 1983/02/01 00:00
PHST- 1983/02/01 00:00 [pubmed]
PHST- 1983/02/01 00:01 [medline]
PHST- 1983/02/01 00:00 [entrez]
AID - 10.1210/endo-112-2-715 [doi]
PST - ppublish
SO  - Endocrinology. 1983 Feb;112(2):715-9. doi: 10.1210/endo-112-2-715.