PMID- 6404575
OWN - NLM
STAT- MEDLINE
DCOM- 19830610
LR  - 20190825
IS  - 0305-1870 (Print)
IS  - 0305-1870 (Linking)
VI  - 10
IP  - 1
DP  - 1983 Jan-Feb
TI  - Effects of neonatal sympathectomy by 6-hydroxydopamine on blood pressure and 
      intravascular volume in young stroke-prone spontaneously hypertensive rats.
PG  - 27-33
AB  - 1. Stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive Wistar 
      Kyoto rats (WKY) were 'chemically sympathectomized' immediately after birth with 
      6-hydroxydopamine (6-OHDA, 100 mg/kg s.c. daily) for the first 10 days of life. 
      2. Body weight gain was diminished in both groups as compared with sham-treated 
      controls. Blood pressure was reduced in 'sympathectomized' SHRSP, and also WKY 
      rats had a slightly lower blood pressure than control rats. 3. Plasma 
      concentration of angiotensin II and renin content of the kidney were not 
      influenced by 6-OHDA. 4. 'Sympathectomized' SHRSP retained similar amounts of 
      sodium than sham-treated SHRSP when sodium retention is expressed per body weight 
      gained. Plasma and blood volumes were increased in both SHRSP and WKY rats, 
      whereas packed cell volume was significantly decreased. 5. These results 
      demonstrate the significance of an intact sympathetic nervous system for the 
      development of hypertension in SHRSP. The expanded plasma and blood volume in 
      'sympathectomized' rats indicate an important role of the sympathetic nervous 
      system and/or the arterial blood pressure for the regulation of intravascular 
      volume.
FAU - Rascher, W
AU  - Rascher W
FAU - Dietz, R
AU  - Dietz R
FAU - Schomig, A
AU  - Schomig A
FAU - Voss, U
AU  - Voss U
FAU - Gross, F
AU  - Gross F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Clin Exp Pharmacol Physiol
JT  - Clinical and experimental pharmacology & physiology
JID - 0425076
RN  - 0 (Hydroxydopamines)
RN  - 11128-99-7 (Angiotensin II)
RN  - 8HW4YBZ748 (Oxidopamine)
RN  - 9NEZ333N27 (Sodium)
RN  - EC 3.4.23.15 (Renin)
SB  - IM
MH  - Angiotensin II/metabolism
MH  - Animals
MH  - Animals, Newborn/physiology
MH  - Blood Pressure/*drug effects
MH  - Blood Volume/*drug effects
MH  - Body Weight/drug effects
MH  - Cerebrovascular Disorders/etiology/*physiopathology
MH  - Hydroxydopamines/pharmacology
MH  - Hypertension/complications/*physiopathology
MH  - Male
MH  - Oxidopamine
MH  - Plasma Volume/drug effects
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Renin/metabolism
MH  - Sodium/metabolism
MH  - *Sympathectomy, Chemical
EDAT- 1983/01/01 00:00
MHDA- 1983/01/01 00:01
CRDT- 1983/01/01 00:00
PHST- 1983/01/01 00:00 [pubmed]
PHST- 1983/01/01 00:01 [medline]
PHST- 1983/01/01 00:00 [entrez]
AID - 10.1111/j.1440-1681.1983.tb00168.x [doi]
PST - ppublish
SO  - Clin Exp Pharmacol Physiol. 1983 Jan-Feb;10(1):27-33. doi: 
      10.1111/j.1440-1681.1983.tb00168.x.