PMID- 6410414
OWN - NLM
STAT- MEDLINE
DCOM- 19830923
LR  - 20191031
IS  - 0262-1746 (Print)
IS  - 0262-1746 (Linking)
VI  - 11
IP  - 1
DP  - 1983 May
TI  - The effects of aspirin and dipyridamole on the metabolism of arachidonic acid in 
      human platelets.
PG  - 73-82
AB  - The effects of aspirin and dipyridamole on the metabolism of exogenous 
      14C-arachidonic acid were investigated in intact human platelets in vitro. The 
      formation of thromboxane B2 (TXB2) and 12-hydroxy-5,8,10-heptadecatrienoic acid 
      (HHT) was inhibited dose dependently by aspirin but not by dipyridamole. Neither 
      was the aspirin caused inhibition in TXB2 and HHT formation modified by 
      dipyridamole. At high concentrations aspirin caused a slight increase in the 
      amount of 12-hydroperoxy-5,8,10,14-eicosatetraenoic acid (12-HPETE) and a 
      corresponding decrease in that of 12-hydroxy-5,8,10,14-eicosatetraenoic acid 
      (12-HETE). This was seen also when aspirin was combined with dipyridamole. At 
      high concentrations (100 microM and 1 mM) dipyridamole caused an increased 
      formation of 12-HETE and an unidentified metabolite group. The present study 
      indicates that dipyridamole has no effect on the formation of the cyclo-oxygenase 
      metabolites in human platelets but the lipoxygenase pathway seems to be 
      stimulated by dipyridamole.
FAU - Uotila, P
AU  - Uotila P
FAU - Dahl, M L
AU  - Dahl ML
FAU - Matintalo, M
AU  - Matintalo M
FAU - Puustinen, T
AU  - Puustinen T
LA  - eng
GR  - HL-30110/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Scotland
TA  - Prostaglandins Leukot Med
JT  - Prostaglandins, leukotrienes, and medicine
JID - 8206868
RN  - 0 (Arachidonic Acids)
RN  - 0 (Fatty Acids, Unsaturated)
RN  - 0 (Leukotrienes)
RN  - 27YG812J1I (Arachidonic Acid)
RN  - 54397-85-2 (Thromboxane B2)
RN  - 59985-28-3 (12-Hydroxy-5,8,10,14-eicosatetraenoic Acid)
RN  - 64ALC7F90C (Dipyridamole)
RN  - 67675-13-2 (12-HPETE)
RN  - 74004-31-2 (12-hydroxy-5,8,10,14-heptadectetraenoic acid)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
MH  - Adult
MH  - Arachidonic Acid
MH  - Arachidonic Acids/*metabolism
MH  - Aspirin/*pharmacology
MH  - Blood Platelets/drug effects/*metabolism
MH  - Dipyridamole/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Fatty Acids, Unsaturated/metabolism
MH  - Humans
MH  - In Vitro Techniques
MH  - *Leukotrienes
MH  - Male
MH  - Thromboxane B2/metabolism
EDAT- 1983/05/01 00:00
MHDA- 1983/05/01 00:01
CRDT- 1983/05/01 00:00
PHST- 1983/05/01 00:00 [pubmed]
PHST- 1983/05/01 00:01 [medline]
PHST- 1983/05/01 00:00 [entrez]
AID - 10.1016/0262-1746(83)90111-7 [doi]
PST - ppublish
SO  - Prostaglandins Leukot Med. 1983 May;11(1):73-82. doi: 
      10.1016/0262-1746(83)90111-7.