PMID- 6415179
OWN - NLM
STAT- MEDLINE
DCOM- 19831217
LR  - 20220408
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 148
IP  - 4
DP  - 1983 Oct
TI  - Human leukocyte antigen (HLA)-linked control of susceptibility to pulmonary 
      tuberculosis and association with HLA-DR types.
PG  - 676-81
AB  - To demonstrate human leukocyte antigen (HLA)-linked control of susceptibility to 
      pulmonary tuberculosis, 25 multiple-case families were tissue typed for class I 
      and class II HLA specificities. Eight non-HLA genetic markers were also examined 
      for any indication of other genetic factors that might influence the 
      Mycobacterium tuberculosis infection. Observations on estimated HLA haplotype 
      segregation in the sibs suggest that 84% of the affected sibs shared 
      significantly more often than expected a common haplotype with each other than 
      the normal unaffected sibs (P less than 0.001). Also, there was a skewed 
      transmission of DR2 to diseased offspring from diseased parents (21 of 27) and to 
      diseased offspring from healthy parents (15 of 17) in contrast to the 
      transmission of DR2 from either group of parents to healthy offspring (six of 15 
      and 10 of 16, respectively). The segregation of non-HLA polymorphisms did not 
      deviate significantly from the expected figures. These data provide strong 
      evidence in favor of DR2-associated susceptibility to pulmonary tuberculosis.
FAU - Singh, S P
AU  - Singh SP
FAU - Mehra, N K
AU  - Mehra NK
FAU - Dingley, H B
AU  - Dingley HB
FAU - Pande, J N
AU  - Pande JN
FAU - Vaidya, M C
AU  - Vaidya MC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Genetic Markers)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adult
MH  - Child
MH  - Disease Susceptibility
MH  - Ethnicity
MH  - Female
MH  - Genes, MHC Class II
MH  - *Genetic Linkage
MH  - Genetic Markers
MH  - Genotype
MH  - HLA Antigens/analysis/genetics/*immunology
MH  - HLA-DR Antigens
MH  - Haploidy
MH  - Histocompatibility Antigens Class II/analysis/*immunology
MH  - Humans
MH  - Male
MH  - Polymorphism, Genetic
MH  - Tuberculosis, Pulmonary/genetics/*immunology
EDAT- 1983/10/01 00:00
MHDA- 1983/10/01 00:01
CRDT- 1983/10/01 00:00
PHST- 1983/10/01 00:00 [pubmed]
PHST- 1983/10/01 00:01 [medline]
PHST- 1983/10/01 00:00 [entrez]
AID - 10.1093/infdis/148.4.676 [doi]
PST - ppublish
SO  - J Infect Dis. 1983 Oct;148(4):676-81. doi: 10.1093/infdis/148.4.676.