PMID- 6415919
OWN - NLM
STAT- MEDLINE
DCOM- 19831217
LR  - 20190819
IS  - 0042-9007 (Print)
IS  - 0042-9007 (Linking)
VI  - 45
IP  - 4
DP  - 1983
TI  - Platelet concentrates stored at 22 degrees C need oxygen. The significance of 
      plastics in platelet preservation.
PG  - 303-11
AB  - Platelet concentrates prepared by platelet apheresis were stored in plastic blood 
      bags with different gas permeability properties. Inadequate oxygen supply gave an 
      insufficient adenosine triphosphate (ATP) regeneration and a compensatory 
      increase in glycolysis and lactic acid production, giving a rapidly falling pH. 
      At pH below 6.0 the glycolysis was inhibited, oxygen consumption ceased, and ATP 
      dropped towards depletion. Adequate oxygen supply kept the lactic acid production 
      low with small pH changes only, and allowed a sufficient ATP regeneration. The 
      release of alpha-granular platelet Factor 4 (PF4) was almost total at pH below 
      6.0, while at intact metabolic function there was a slow release of PF4. Platelet 
      preservation is enhanced by the use of blood bags with adequate gas exchange 
      properties. In our study one polyvinyl chloride plastic (PVC) bag gave poor 
      results, while another PVC bag and a polyolefin bag showed intact metabolism for 
      5 days and a moderate release of PF4.
FAU - Wallvik, J
AU  - Wallvik J
FAU - Akerblom, O
AU  - Akerblom O
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Vox Sang
JT  - Vox sanguinis
JID - 0413606
RN  - 0 (Blood Glucose)
RN  - 0 (Lactates)
RN  - 0 (Plastics)
RN  - 142M471B3J (Carbon Dioxide)
RN  - 37270-94-3 (Platelet Factor 4)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
SB  - IM
MH  - Adenosine Triphosphate/blood
MH  - Blood Glucose/metabolism
MH  - *Blood Platelets/metabolism
MH  - *Blood Preservation
MH  - Carbon Dioxide/blood
MH  - Humans
MH  - In Vitro Techniques
MH  - Lactates/blood
MH  - Oxygen Consumption
MH  - Plastics
MH  - Platelet Factor 4/analysis
EDAT- 1983/01/01 00:00
MHDA- 1983/01/01 00:01
CRDT- 1983/01/01 00:00
PHST- 1983/01/01 00:00 [pubmed]
PHST- 1983/01/01 00:01 [medline]
PHST- 1983/01/01 00:00 [entrez]
AID - 10.1111/j.1423-0410.1983.tb01918.x [doi]
PST - ppublish
SO  - Vox Sang. 1983;45(4):303-11. doi: 10.1111/j.1423-0410.1983.tb01918.x.