PMID- 6417674
OWN - NLM
STAT- MEDLINE
DCOM- 19840107
LR  - 20191031
IS  - 0262-1746 (Print)
IS  - 0262-1746 (Linking)
VI  - 12
IP  - 2
DP  - 1983 Oct
TI  - Changes in arachidonate metabolism in aortas and platelets in aging rats.
PG  - 149-57
AB  - Prostacyclin formation by aortas, thromboxane biosynthesis and 12-lipoxygenase 
      pathway in platelets as a function of age was investigated. Our results indicate 
      an age-related decrease in prostacyclin production by aortas, while no 
      significant change in thromboxane biosynthesis in platelets from mature (12 month 
      old) to senescent (24 month old) rats was observed. Evidence is also presented 
      indicating a decrease in 12-L-hydroperoxy-5,8,10,14-eicosatetraenoic acid 
      (12-HPETE) peroxidase activity in platelets as a function of age.
FAU - Chang, W C
AU  - Chang WC
FAU - Tai, H H
AU  - Tai HH
LA  - eng
GR  - GM-30380/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Scotland
TA  - Prostaglandins Leukot Med
JT  - Prostaglandins, leukotrienes, and medicine
JID - 8206868
RN  - 0 (Arachidonic Acids)
RN  - 0 (Carbon Radioisotopes)
RN  - 27YG812J1I (Arachidonic Acid)
RN  - 54397-85-2 (Thromboxane B2)
RN  - 58962-34-8 (6-Ketoprostaglandin F1 alpha)
SB  - IM
MH  - 6-Ketoprostaglandin F1 alpha/biosynthesis
MH  - Aging
MH  - Animals
MH  - Aorta, Thoracic/*growth & development/metabolism
MH  - Arachidonic Acid
MH  - Arachidonic Acids/*metabolism
MH  - Blood Platelets/*metabolism
MH  - Carbon Radioisotopes
MH  - Male
MH  - Rats
MH  - Rats, Inbred F344
MH  - Thromboxane B2/blood
EDAT- 1983/10/01 00:00
MHDA- 1983/10/01 00:01
CRDT- 1983/10/01 00:00
PHST- 1983/10/01 00:00 [pubmed]
PHST- 1983/10/01 00:01 [medline]
PHST- 1983/10/01 00:00 [entrez]
AID - 10.1016/0262-1746(83)90078-1 [doi]
PST - ppublish
SO  - Prostaglandins Leukot Med. 1983 Oct;12(2):149-57. doi: 
      10.1016/0262-1746(83)90078-1.