PMID- 6422007
OWN - NLM
STAT- MEDLINE
DCOM- 19840412
LR  - 20170210
IS  - 0732-183X (Print)
IS  - 0732-183X (Linking)
VI  - 1
IP  - 9
DP  - 1983 Sep
TI  - Four-drug combination chemotherapy (methotrexate, cyclophosphamide, 
      hexamethylmelamine, and CCNU) for non-small cell bronchogenic carcinoma: a Cancer 
      and Leukemia Group B study.
PG  - 559-65
AB  - Ninety-eight evaluable patients with nonresectable regional or metastatic 
      non-small cell bronchogenic carcinoma were treated with a four-drug combination 
      chemotherapy program of methotrexate, cyclophosphamide, hexamethylmelamine, and 
      CCNU (MCHC). Fifteen partial or complete responses (15%) were obtained, all but 
      one of which occurred in good performance status (0-1) patients. While 
      "responders lived longer than non-responders", this was due more to initial 
      performance status among responding patients than to achievement of partial 
      (greater than 50%) or complete disease regression. Evaluation of those patients 
      with good performance status (PS 0-1), indicated no statistically significant 
      differences in median survival time for complete response and partial response 
      patients compared to patients with "improved" or "stable" disease status in this 
      group. This combination of modestly active single agents produced disappointing 
      results in our lung cancer population. A search for more active single agents in 
      lung cancer is necessary.
FAU - Green, M
AU  - Green M
FAU - Horton, C
AU  - Horton C
FAU - Spaulding, M
AU  - Spaulding M
FAU - Silver, R T
AU  - Silver RT
FAU - Berenberg, J
AU  - Berenberg J
FAU - Kennedy, B J
AU  - Kennedy BJ
FAU - Pajak, T F
AU  - Pajak TF
FAU - Comis, R
AU  - Comis R
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Clin Oncol
JT  - Journal of clinical oncology : official journal of the American Society of 
      Clinical Oncology
JID - 8309333
RN  - 7BRF0Z81KG (Lomustine)
RN  - 8N3DW7272P (Cyclophosphamide)
RN  - Q8BIH59O7H (Altretamine)
RN  - YL5FZ2Y5U1 (Methotrexate)
RN  - MCHC protocol
SB  - IM
CIN - J Clin Oncol. 2008 Jul 1;26(19):3112-3. PMID: 18591551
MH  - Altretamine/administration & dosage/adverse effects/therapeutic use
MH  - Antineoplastic Combined Chemotherapy Protocols/adverse effects/*therapeutic use
MH  - Carcinoma, Bronchogenic/diagnosis/*drug therapy/mortality
MH  - Clinical Trials as Topic
MH  - Cyclophosphamide/administration & dosage/adverse effects/therapeutic use
MH  - Female
MH  - Humans
MH  - Lomustine/administration & dosage/adverse effects/therapeutic use
MH  - Lung Neoplasms/diagnosis/*drug therapy/mortality
MH  - Male
MH  - Methotrexate/administration & dosage/adverse effects/therapeutic use
EDAT- 1983/09/01 00:00
MHDA- 1983/09/01 00:01
CRDT- 1983/09/01 00:00
PHST- 1983/09/01 00:00 [pubmed]
PHST- 1983/09/01 00:01 [medline]
PHST- 1983/09/01 00:00 [entrez]
AID - 10.1200/JCO.1983.1.9.559 [doi]
PST - ppublish
SO  - J Clin Oncol. 1983 Sep;1(9):559-65. doi: 10.1200/JCO.1983.1.9.559.