PMID- 6425908
OWN - NLM
STAT- MEDLINE
DCOM- 19840530
LR  - 20191210
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 82
IP  - 3
DP  - 1984
TI  - Reinforcing properties of morphine and naloxone revealed by conditioned place 
      preferences: a procedural examination.
PG  - 241-7
AB  - In rats, conditioned place preferences are produced by morphine and conditioned 
      place aversions produced by naloxone. In the present studies, several issues 
      concerning the demonstration and interpretation of place conditioning findings 
      were examined in a two-compartment (black and white) tilt box: (1) the responses 
      of naive rats to testing, (2) place conditioning in rats with strong 
      unconditioned biases to one of the sides, and (3) modifications of the testing 
      situation so that naive rats respond to the black and white sides with a minimum 
      of initial bias. Experiments involving manipulation of the conditions of training 
      and testing, use of pentobarbital, and use of a three-compartment test box helped 
      to control for morphine's ability to produce state dependent learning as an 
      explanation of its conditioned place preference. In addition, we examined 
      previous place conditioning studies that failed to show aversive effects of 
      naloxone. These negative findings were suggested to be due to the use or 
      procedures insensitive to aversive stimuli and to the IP administration of 
      naloxone. Finally, in the course of the experiments, novel data on general 
      parameters of the place conditioning were provided. Dose-response curves for 
      subcutaneous (SC) morphine (0.04-5.0 mg/kg) and naloxone (0.02-5.0 mg/kg) were 
      established. Conditioned preferences were also shown to occur after at three 
      pairings of SC drug, and they were retained for at least 1 month.
FAU - Mucha, R F
AU  - Mucha RF
FAU - Iversen, S D
AU  - Iversen SD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 36B82AMQ7N (Naloxone)
RN  - 76I7G6D29C (Morphine)
RN  - YQE403BP4D (Phenobarbital)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Conditioning, Psychological/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Male
MH  - Morphine/*pharmacology
MH  - Naloxone/*pharmacology
MH  - Phenobarbital/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Reinforcement, Psychology/*drug effects
EDAT- 1984/01/01 00:00
MHDA- 1984/01/01 00:01
CRDT- 1984/01/01 00:00
PHST- 1984/01/01 00:00 [pubmed]
PHST- 1984/01/01 00:01 [medline]
PHST- 1984/01/01 00:00 [entrez]
AID - 10.1007/BF00427782 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 1984;82(3):241-7. doi: 10.1007/BF00427782.