PMID- 6429563
OWN - NLM
STAT- MEDLINE
DCOM- 19840801
LR  - 20191210
IS  - 0028-3908 (Print)
IS  - 0028-3908 (Linking)
VI  - 23
IP  - 5
DP  - 1984 May
TI  - Discrimination of the amphetamine cue. Effects of A, B and mixed type inhibitors 
      of monoamine oxidase.
PG  - 569-73
AB  - Rats were trained to discriminate between the effects of 0.6 mg/kg of 
      (+)-amphetamine given intraperitoneally saline in a two-lever operant task, 
      according to a fixed ratio ( FR10 ) schedule of food reinforcement. Once trained 
      (greater than 90% responding on the appropriate lever during sessions with drug 
      and saline, respectively over 2 weeks), they were given tests of generalization 
      with various type A, type B or mixed type monoamine oxidase inhibitors (MAOI). 
      Generalization was tested during the first 100 sec of a 15 min trial during which 
      no reinforcements were given (extinction) followed by reinforcement on both 
      levers for the rest of the session. Generalization to amphetamine was estimated 
      using both the percentage of responding on the "drug lever" and a measure of 
      choice of lever. None of the type A MAOI's tested [ cimoxatone (MD 780515), 
      clorgyline, LY 51641, moclobemide (Ro 11-1163), toloxatone] showed generalization 
      towards the lever for amphetamine. Clear or partial amphetamine-like responding 
      was observed with the B type MAOI (+/-)-deprenyl and LY 54761 but not with two 
      other type B MAOI's MD 240928 or pargyline. (+/-)-Tranylcypromine, but not 
      nialamide (mixed type MAOI's), induced dose-dependent responding on the lever for 
      amphetamine. It was concluded that amphetamine-like activity was not an intrinsic 
      property of A or B type MAOI's.
FAU - Porsolt, R D
AU  - Porsolt RD
FAU - Pawelec, C
AU  - Pawelec C
FAU - Roux, S
AU  - Roux S
FAU - Jalfre, M
AU  - Jalfre M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 0 (Cyclopropanes)
RN  - 0 (Monoamine Oxidase Inhibitors)
RN  - 2K1V7GP655 (Selegiline)
RN  - 5388-85-2 (Lilly 51641)
RN  - CK833KGX7E (Amphetamine)
SB  - IM
MH  - Amphetamine/*pharmacology
MH  - Animals
MH  - *Cues
MH  - Cyclopropanes/pharmacology
MH  - Discrimination Learning/drug effects
MH  - Discrimination, Psychological/drug effects
MH  - Male
MH  - Monoamine Oxidase Inhibitors/*pharmacology
MH  - Rats
MH  - Selegiline/pharmacology
EDAT- 1984/05/01 00:00
MHDA- 1984/05/01 00:01
CRDT- 1984/05/01 00:00
PHST- 1984/05/01 00:00 [pubmed]
PHST- 1984/05/01 00:01 [medline]
PHST- 1984/05/01 00:00 [entrez]
AID - 10.1016/0028-3908(84)90031-5 [doi]
PST - ppublish
SO  - Neuropharmacology. 1984 May;23(5):569-73. doi: 10.1016/0028-3908(84)90031-5.