PMID- 6430336
OWN - NLM
STAT- MEDLINE
DCOM- 19840917
LR  - 20151119
IS  - 0007-1048 (Print)
IS  - 0007-1048 (Linking)
VI  - 57
IP  - 4
DP  - 1984 Aug
TI  - The interpretation of platelet kinetic studies for the identification of sites of 
      abnormal platelet destruction.
PG  - 637-49
AB  - The kinetics of platelets labelled with 111In have been studied in a series of 
      175 subjects including 18 normal volunteers, and 12 patients with idiopathic 
      thrombocytopenic purpura (ITP), but excluding patients in whom there was 
      scintigraphic evidence of intravascular platelet consumption. From analysis of 
      the kinetics, the following parameters were calculated: splenic blood flow (SBF), 
      intrasplenic platelet transit time (t-), splenic platelet pool capacity 
      (expressed as a percentage of the total circulating platelet population), the 
      fraction of the dose of labelled platelets ultimately destroyed in the spleen and 
      the mean platelet life span (MPLS). SBF increased with increasing spleen size up 
      to values of 25% total blood volume (TBV) per min. Some patients with immune 
      complex related diseases were identified with elevated SBF (up to 24% TBV min-1) 
      but without significant splenomegaly. Patients with cardiac decompensation had 
      reduced SBF relative to spleen size. t- showed no relationship with spleen size. 
      It tended to fall in patients who had high SBF relative to spleen size and to 
      rise in those with low SBF relative to spleen size; i.e. it was inversely related 
      to splenic perfusion (flow per unit tissue volume). The splenic platelet pool 
      capacity is dependent on platelet input (SBF) and splenic platelet clearance 
      (reciprocal of t-), and showed a close relationship with spleen size. When all 
      subjects except those with ITP were considered, splenic platelet destruction 
      showed a good correlation (r = 0.70, n = 42, P less than 0.001) with the splenic 
      platelet pooling capacity. The ratio of the fraction of platelets destroyed in 
      the spleen to the fraction pooling there, the D/P ratio, was approximately unity 
      and did not appear to vary with MPLS, spleen size or the patient's condition, 
      except in ITP where it varied between about 0.5 and 2. This variation in ITP was 
      thought to be the result of an immune mediated re-direction of 
      reticulo-endothelial platelet destruction. It is suggested that the D/P ratio, 
      rather than the absolute quantity of 111In labelled platelets destroyed in the 
      spleen, may be a more useful predictor of response to splenectomy since it takes 
      into account the observed, appropriate, tendency for the spleen to destroy 
      platelets in proportion to its platelet pooling capacity.
FAU - Peters, A M
AU  - Peters AM
FAU - Saverymuttu, S H
AU  - Saverymuttu SH
FAU - Wonke, B
AU  - Wonke B
FAU - Lewis, S M
AU  - Lewis SM
FAU - Lavender, J P
AU  - Lavender JP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
RN  - 0 (Organometallic Compounds)
RN  - 0 (Pentanones)
RN  - 0 (Radioisotopes)
RN  - 045A6V3VFX (Indium)
RN  - 14514-42-2 (indium oxine)
RN  - 46R950BP4J (acetylacetone)
RN  - 5UTX5635HP (Oxyquinoline)
SB  - IM
MH  - Blood Flow Velocity
MH  - Blood Platelets/*physiology
MH  - Cell Survival
MH  - Humans
MH  - Indium
MH  - *Organometallic Compounds
MH  - Oxyquinoline/analogs & derivatives
MH  - Pentanones
MH  - Purpura, Thrombocytopenic/*blood/pathology/physiopathology
MH  - Radioisotopes
MH  - Spleen/blood supply/pathology
MH  - Time Factors
EDAT- 1984/08/01 00:00
MHDA- 1984/08/01 00:01
CRDT- 1984/08/01 00:00
PHST- 1984/08/01 00:00 [pubmed]
PHST- 1984/08/01 00:01 [medline]
PHST- 1984/08/01 00:00 [entrez]
PST - ppublish
SO  - Br J Haematol. 1984 Aug;57(4):637-49.