PMID- 6430467
OWN - NLM
STAT- MEDLINE
DCOM- 19840824
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 304
IP  - 2
DP  - 1984 Jun 25
TI  - Additional evidence that the suprachiasmatic nucleus is the center for regulation 
      of insulin secretion and glucose homeostasis.
PG  - 237-41
AB  - The role of the suprachiasmatic nucleus (SCN) in photoperiod-dependent 
      hyperglycemia due to D-mannitol (MA) and D-glucose (GL) was investigated using 
      SCN-lesioned rats. In control rats, intracranial injection of MA and GL caused 
      hyperglycemia only in the light period and dark period, respectively. In 
      SCN-lesioned rats, administration of MA and GL caused no change in plasma glucose 
      level, irrespective of the lighting condition. SCN-lesioned rats have higher 
      plasma insulin levels than sham-operated rats through this experiment. From these 
      findings, we propose that the SCN is involved in a glucose homeostasis and 
      regulation of insulin secretion.
FAU - Yamamoto, H
AU  - Yamamoto H
FAU - Nagai, K
AU  - Nagai K
FAU - Nakagawa, H
AU  - Nakagawa H
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 3OWL53L36A (Mannitol)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - Blood Glucose/*metabolism
MH  - Brain Mapping
MH  - Glucose/pharmacology
MH  - Hypothalamic Area, Lateral/physiology
MH  - Hypothalamus, Middle/physiology
MH  - Insulin/*metabolism
MH  - Insulin Secretion
MH  - Light
MH  - Male
MH  - Mannitol/pharmacology
MH  - Periodicity
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Suprachiasmatic Nucleus/*physiology
EDAT- 1984/06/25 00:00
MHDA- 1984/06/25 00:01
CRDT- 1984/06/25 00:00
PHST- 1984/06/25 00:00 [pubmed]
PHST- 1984/06/25 00:01 [medline]
PHST- 1984/06/25 00:00 [entrez]
AID - 0006-8993(84)90326-3 [pii]
AID - 10.1016/0006-8993(84)90326-3 [doi]
PST - ppublish
SO  - Brain Res. 1984 Jun 25;304(2):237-41. doi: 10.1016/0006-8993(84)90326-3.