PMID- 6431893
OWN - NLM
STAT- MEDLINE
DCOM- 19840918
LR  - 20041117
IS  - 0091-7370 (Print)
IS  - 0091-7370 (Linking)
VI  - 14
IP  - 4
DP  - 1984 Jul-Aug
TI  - Characteristics and natural history of alloimmunization following HLA-matched 
      leukocyte transfusion in Hunter's syndrome.
PG  - 276-84
AB  - The characteristics and natural history of alloimmunization to HLA were studied 
      in five patients with Hunter's syndrome receiving long term transfusions of 
      leukocytes collected from human leukocyte antigen (HLA) matched donors. Patients 
      were not given any other blood component transfusions. All patients became 
      alloimmunized at an average interval of eight months following an average of 15 
      transfusions. All patients developed HLA alloantibodies to transfused 
      cross-reactive HLA antigens. Antibodies to transfused incompatible HLA antigens 
      also developed in all patients. Multispecific HLA antibodies in which specificity 
      determination could not be made were also seen in four patients. In a small 
      number of patients in this study, despite matching for the private HLA 
      specificities, HLA alloimmunization was not prevented. In fact, broad 
      alloimmunization was seen uniformly in our patients.
FAU - Kakaiya, R K
AU  - Kakaiya RK
FAU - Greenstein, R
AU  - Greenstein R
FAU - Pisciotto, P T
AU  - Pisciotto PT
FAU - Slocum, S K
AU  - Slocum SK
FAU - Rosen, D
AU  - Rosen D
FAU - Cable, R G
AU  - Cable RG
FAU - Morse, E E
AU  - Morse EE
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Clin Lab Sci
JT  - Annals of clinical and laboratory science
JID - 0410247
RN  - 0 (HLA Antigens)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - Adult
MH  - Antibody Formation
MH  - *Blood Transfusion
MH  - Child
MH  - Child, Preschool
MH  - HLA Antigens/analysis/*immunology
MH  - Humans
MH  - Isoantibodies/immunology
MH  - Leukocyte Transfusion
MH  - Leukocytes/*immunology
MH  - Male
MH  - *Mucopolysaccharidosis II/blood/*immunology
EDAT- 1984/07/01 00:00
MHDA- 1984/07/01 00:01
CRDT- 1984/07/01 00:00
PHST- 1984/07/01 00:00 [pubmed]
PHST- 1984/07/01 00:01 [medline]
PHST- 1984/07/01 00:00 [entrez]
PST - ppublish
SO  - Ann Clin Lab Sci. 1984 Jul-Aug;14(4):276-84.