PMID- 6432748
OWN - NLM
STAT- MEDLINE
DCOM- 19841024
LR  - 20190708
IS  - 0360-3016 (Print)
IS  - 0360-3016 (Linking)
VI  - 10
IP  - 8
DP  - 1984 Aug
TI  - Radiation and concurrent chemotherapy for the treatment of Lewis lung tumor and 
      B16 melanoma tumor in C57/BL mice.
PG  - 1479-82
AB  - C57/BL mice bearing either Lewis lung tumor or B16 melanoma tumor were treated 
      with radiation and concurrent chemotherapy. The treatment results were determined 
      in vivo by tumor regrowth delay assay. When continuous infusion of either 
      Cyclophosphamide (CYCLO) or 5-Fluorouracil (5-FU) or Adriamycin (ADRIA) or 
      Mitomycin-C (MITO-C) was used in combination with continuous radiation at 1 
      cGy/min, no increase in tumor regrowth delay was observed over that of radiation 
      alone. When multiple drug chemotherapy, FAM (5-FU, ADRIA, MITO-C) was 
      administered in combination with radiation at 80 cGy/min, no increase in tumor 
      regrowth delay was observed over that of radiation alone. In these two murine 
      tumor models, when clinically relevant concentrations of commonly used 
      chemotherapy agents were combined with radiation, no therapeutic advantage was 
      observed.
FAU - Pedersen, J E
AU  - Pedersen JE
FAU - Barron, G
AU  - Barron G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Cesium Radioisotopes)
RN  - 0 (Cobalt Radioisotopes)
RN  - 0 (Mitomycins)
RN  - 50SG953SK6 (Mitomycin)
RN  - 80168379AG (Doxorubicin)
RN  - 8N3DW7272P (Cyclophosphamide)
RN  - U3P01618RT (Fluorouracil)
RN  - FAM protocol
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/*therapeutic use
MH  - Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
MH  - Cesium Radioisotopes/*therapeutic use
MH  - Cobalt Radioisotopes/*therapeutic use
MH  - Combined Modality Therapy
MH  - Cyclophosphamide/therapeutic use
MH  - Doxorubicin/administration & dosage/therapeutic use
MH  - Fluorouracil/administration & dosage/therapeutic use
MH  - Lung Neoplasms/*therapy
MH  - Melanoma/*therapy
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mitomycin
MH  - Mitomycins/administration & dosage/therapeutic use
MH  - Neoplasm Transplantation
MH  - Radiotherapy Dosage
EDAT- 1984/08/01 00:00
MHDA- 1984/08/01 00:01
CRDT- 1984/08/01 00:00
PHST- 1984/08/01 00:00 [pubmed]
PHST- 1984/08/01 00:01 [medline]
PHST- 1984/08/01 00:00 [entrez]
AID - 0360-3016(84)90372-9 [pii]
AID - 10.1016/0360-3016(84)90372-9 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 1984 Aug;10(8):1479-82. doi: 
      10.1016/0360-3016(84)90372-9.