PMID- 6435708
OWN - NLM
STAT- MEDLINE
DCOM- 19841128
LR  - 20190511
IS  - 0007-1188 (Print)
IS  - 0007-1188 (Linking)
VI  - 83
IP  - 1
DP  - 1984 Sep
TI  - Structure-antinociceptive activity studies with neurotensin.
PG  - 43-8
AB  - The antinociceptive effects of synthetic neurotensin (NT), its fragments and 
      analogues administered into the lateral cerebroventricle have been compared in 
      the conscious mouse. Intracerebroventricular (i.c.v.) administration of NT 
      produced a dose-dependent antinociceptive effect in the tail pressure test. The 
      NT fragments and analogues, NT(8-13), NT(8-10), NT(9-13), NT(9-11), NT(8-11) NHEt 
      and NT(9-11) NHEt were also effective antinociceptive peptides. The potency of 
      NT(8-13) and the duration of its effects were found to be approximately equal to 
      those of NT. The antinociceptive effects produced by NT, NT(8-13) and NT(9-13) 
      were significantly reversed by the opioid antagonist naloxone but not by 
      thyrotropin releasing hormone. It is concluded that NT(8-13) is required for the 
      full expression of the antinociceptive effects of NT which may be mediated in 
      part through the brain opioid system.
FAU - Furuta, S
AU  - Furuta S
FAU - Kisara, K
AU  - Kisara K
FAU - Sakurada, S
AU  - Sakurada S
FAU - Sakurada, T
AU  - Sakurada T
FAU - Sasaki, Y
AU  - Sasaki Y
FAU - Suzuki, K
AU  - Suzuki K
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Pharmacol
JT  - British journal of pharmacology
JID - 7502536
RN  - 0 (Analgesics)
RN  - 0 (Peptide Fragments)
RN  - 36B82AMQ7N (Naloxone)
RN  - 39379-15-2 (Neurotensin)
RN  - 5Y5F15120W (Thyrotropin-Releasing Hormone)
SB  - IM
MH  - *Analgesics
MH  - Animals
MH  - Injections, Intraventricular
MH  - Male
MH  - Mice
MH  - Naloxone/pharmacology
MH  - Neurotensin/analogs & derivatives/*pharmacology
MH  - Peptide Fragments/pharmacology
MH  - Structure-Activity Relationship
MH  - Thyrotropin-Releasing Hormone/pharmacology
MH  - Time Factors
PMC - PMC1987165
EDAT- 1984/09/01 00:00
MHDA- 1984/09/01 00:01
PMCR- 1985/09/01
CRDT- 1984/09/01 00:00
PHST- 1984/09/01 00:00 [pubmed]
PHST- 1984/09/01 00:01 [medline]
PHST- 1984/09/01 00:00 [entrez]
PHST- 1985/09/01 00:00 [pmc-release]
AID - 10.1111/j.1476-5381.1984.tb10117.x [doi]
PST - ppublish
SO  - Br J Pharmacol. 1984 Sep;83(1):43-8. doi: 10.1111/j.1476-5381.1984.tb10117.x.