PMID- 6436128
OWN - NLM
STAT- MEDLINE
DCOM- 19841128
LR  - 20141003
IS  - 0016-450X (Print)
IS  - 0016-450X (Linking)
VI  - 75
IP  - 8
DP  - 1984 Aug
TI  - Dietary carbohydrate level as a modifying factor of 
      3'-methyl-4-dimethylaminoazobenzene liver carcinogenesis in rats.
PG  - 665-71
AB  - The effect of dietary carbohydrate (CHO) level on liver carcinogenesis induced by 
      3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB) was investigated in male Wistar 
      rats. In the first experiment, three groups of 30 rats were maintained on liquid 
      diets, which differed only in the level of CHO (sucrose); high-CHO (14.04 g/day), 
      medium-CHO (9.72 g/day) and low-CHO (3.64 g/day). Half of the animals from each 
      group were given 3'-Me-ADB added to their diet at the level of 10 mg/day/rat for 
      20 weeks, the remainder being maintained as carcinogen-free controls. Final body 
      and liver weights of control rats decreased with decreasing dietary level of CHO, 
      while carcinogen treatment increased the liver/body weight ratio with decreasing 
      CHO level. Quantitative analysis showed that the number and area of liver tumors 
      per unit area of liver sections increased with decreasing dietary sucrose level. 
      Hepatocellular carcinomas were only observed in rats placed on the low-CHO diet 
      (4 out of 15 rats). In the second experiment, where rats were given 3'-Me-DAB in 
      a semisynthetic powder diet for 16 weeks, the number and area of 
      gamma-glutamyltranspeptidase-positive foci were significantly higher in the 
      low-CHO diet group, with decreasing values being associated with increase in 
      sucrose level in the diet. Thus, the present experiments clearly showed that 
      lowered CHO intake enhanced, whereas high intake reduced, 3'-Me-DAB liver 
      carcinogenesis in rats.
FAU - Sato, A
AU  - Sato A
FAU - Nakajima, T
AU  - Nakajima T
FAU - Koyama, Y
AU  - Koyama Y
FAU - Shirai, T
AU  - Shirai T
FAU - Ito, N
AU  - Ito N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Gan
JT  - Gan
JID - 0151745
RN  - 0 (Dietary Carbohydrates)
RN  - 55-80-1 (Methyldimethylaminoazobenzene)
RN  - A49L8E13FD (p-Dimethylaminoazobenzene)
SB  - IM
MH  - Animals
MH  - Biotransformation
MH  - Body Weight/drug effects
MH  - Dietary Carbohydrates/*pharmacology
MH  - Liver Neoplasms, Experimental/*chemically induced
MH  - Male
MH  - *Methyldimethylaminoazobenzene/metabolism
MH  - Organ Size/drug effects
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Riboflavin Deficiency/complications
MH  - *p-Dimethylaminoazobenzene/analogs & derivatives
EDAT- 1984/08/01 00:00
MHDA- 1984/08/01 00:01
CRDT- 1984/08/01 00:00
PHST- 1984/08/01 00:00 [pubmed]
PHST- 1984/08/01 00:01 [medline]
PHST- 1984/08/01 00:00 [entrez]
PST - ppublish
SO  - Gan. 1984 Aug;75(8):665-71.