PMID- 6437309
OWN - NLM
STAT- MEDLINE
DCOM- 19841218
LR  - 20190619
IS  - 0003-4819 (Print)
IS  - 0003-4819 (Linking)
VI  - 101
IP  - 6
DP  - 1984 Dec
TI  - Primary Sjogren's syndrome and other autoimmune diseases in families. Prevalence 
      and immunogenetic studies in six kindreds.
PG  - 748-56
AB  - The relationships of human leukocyte antigen (HLA) and heavy chain immunoglobulin 
      (Gm) haplotypes to disease and autoantibody expression were examined in six large 
      kindreds, each having one or more members with primary Sjogren's syndrome. 
      Various other autoimmune diseases and autoantibodies occurred among the 117 
      relatives in these families. The HLA and Gm haplotypes did not necessarily 
      segregate persons into those with Sjogren's syndrome, other autoimmune disorders, 
      or serologic abnormalities, but HLA alleles DR3 and DR2 occurred in significant 
      excess in relatives with Sjogren's syndrome, irrespective of HLA haplotype. 
      Segregation analysis suggested a Mendelian dominant genetic defect common to the 
      many autoimmune diseases and serologic reactions that was not linked to HLA or 
      Gm. A significant effect of female sex was also documented. These studies suggest 
      that Sjogren's syndrome results from the interaction of several HLA-linked and 
      non-HLA-linked genes.
FAU - Reveille, J D
AU  - Reveille JD
FAU - Wilson, R W
AU  - Wilson RW
FAU - Provost, T T
AU  - Provost TT
FAU - Bias, W B
AU  - Bias WB
FAU - Arnett, F C
AU  - Arnett FC
LA  - eng
GR  - 5 M01RR00722/RR/NCRR NIH HHS/United States
GR  - IP60AM20558/AM/NIADDK NIH HHS/United States
GR  - IT35AM 07384/AM/NIADDK NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Ann Intern Med
JT  - Annals of internal medicine
JID - 0372351
RN  - 0 (Autoantibodies)
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin Heavy Chains)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Alleles
MH  - Autoantibodies/genetics
MH  - Autoimmune Diseases/epidemiology/*genetics/immunology
MH  - Female
MH  - Genes, Dominant
MH  - Genotype
MH  - HLA Antigens/genetics
MH  - Haploidy
MH  - Histocompatibility Antigens Class II/genetics
MH  - Humans
MH  - Immunoglobulin G/genetics
MH  - Immunoglobulin Heavy Chains/genetics
MH  - Male
MH  - Middle Aged
MH  - Pedigree
MH  - Sex Factors
MH  - Sjogren's Syndrome/epidemiology/*genetics/immunology
MH  - Syndrome
MH  - Xerophthalmia/genetics
MH  - Xerostomia/genetics
EDAT- 1984/12/01 00:00
MHDA- 1984/12/01 00:01
CRDT- 1984/12/01 00:00
PHST- 1984/12/01 00:00 [pubmed]
PHST- 1984/12/01 00:01 [medline]
PHST- 1984/12/01 00:00 [entrez]
AID - 10.7326/0003-4819-101-6-748 [doi]
PST - ppublish
SO  - Ann Intern Med. 1984 Dec;101(6):748-56. doi: 10.7326/0003-4819-101-6-748.