PMID- 6438874
OWN - NLM
STAT- MEDLINE
DCOM- 19850124
LR  - 20190829
IS  - 0165-2427 (Print)
IS  - 0165-2427 (Linking)
VI  - 7
IP  - 3-4
DP  - 1984 Oct
TI  - Suppression of IgA synthesis in chickens.
PG  - 305-13
AB  - Four different protocols were tested for the induction of IgA deficiency in 
      chickens: (I) inoculation of anti-alpha intra-peritoneally (i.p.) on alternate 
      days after hatching up to a period of three weeks; (II) bursectomy within 6 h and 
      at 24 h after hatching; (III) in-ovo injection of anti-alpha on the 17th day of 
      embryonation followed by bursectomy at 24 h of hatch and a single injection of 
      anti-alpha i.p. on the day of hatching; (IV) as in III above but bursectomy 
      within 6 h of hatch, followed by three further injections of anti-alpha on days 
      3, 10 and 34 after hatching. Treatment (I) produced temporary 
      dysgammaglobulinemia during the period of treatment. Bursectomy at 24 h of hatch 
      rendered 75% of the chicks IgA deficient up to four weeks of age. Early 
      bursectomy within 6 h of hatch resulted in substantial improvement of IgA 
      suppression. Such chicks, when tested at 4, 6 and 10 weeks of age, were found to 
      be 81, 72 and 58.3% IgA deficient, respectively. With treatment (III) all the 
      treated birds were IgA deficient at four weeks of age. However, as the birds grew 
      older, IgA appeared in the serum so that at the age of 12 weeks only 27.3% were 
      deficient. Treatment (IV) completely suppressed the IgA system of 13 out of 14 
      chickens. These chickens lacked both serum and secretory IgA as well as 
      IgA-containing cells in their intestinal mucosa. Both IgG and IgM continued to be 
      produced.
FAU - Tiwary, B K
AU  - Tiwary BK
FAU - Goel, M C
AU  - Goel MC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Vet Immunol Immunopathol
JT  - Veterinary immunology and immunopathology
JID - 8002006
RN  - 0 (Antibodies, Anti-Idiotypic)
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin alpha-Chains)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Antibodies, Anti-Idiotypic/administration & dosage
MH  - Bursa of Fabricius/immunology
MH  - Chick Embryo
MH  - Chickens
MH  - Disease Models, Animal
MH  - Dysgammaglobulinemia/*etiology
MH  - *IgA Deficiency
MH  - Immunoglobulin A/biosynthesis
MH  - Immunoglobulin alpha-Chains/immunology
EDAT- 1984/10/01 00:00
MHDA- 1984/10/01 00:01
CRDT- 1984/10/01 00:00
PHST- 1984/10/01 00:00 [pubmed]
PHST- 1984/10/01 00:01 [medline]
PHST- 1984/10/01 00:00 [entrez]
AID - 0165-2427(84)90088-6 [pii]
AID - 10.1016/0165-2427(84)90088-6 [doi]
PST - ppublish
SO  - Vet Immunol Immunopathol. 1984 Oct;7(3-4):305-13. doi: 
      10.1016/0165-2427(84)90088-6.