PMID- 6446292
OWN - NLM
STAT- MEDLINE
DCOM- 19800815
LR  - 20190904
IS  - 0300-8428 (Print)
IS  - 0300-8428 (Linking)
VI  - 75
IP  - 1
DP  - 1980 Jan-Feb
TI  - The behavior of some enzymes of the hypertrophied and postnatally developing 
      myocardium of the rat.
PG  - 214-20
AB  - The present study was undertaken in order to investigate the behavior of lactate 
      dehydrogenase (LDH) and hexokinase (HK) in the mechanically overloaded and the 
      postnatally developing left ventricle of the rat. In Goldblatt rats (GBR) 2 to 4 
      months after operation total LDH activity was decreased by 7%, accompanied by an 
      isoenzyme shift towards a higher M proportion. Swimming rats (SR) showed an 11% 
      increase in LDH activity. HK activity was increased by 14% in GBR and unaltered 
      in SR. Histochemical investigations revealed no indication of heterogeneous 
      alterations in various areas of the myocardium. During postnatal development, a 
      gradual increase of activity and H subunit proportion of LDH were observed. HK 
      activity was increased after one week, but underwent a slow decreased thereafter. 
      These changes are interpreted as processes of adaptation to the conditions of 
      extrauterine life.
FAU - Koehler, U
AU  - Koehler U
FAU - Medugorac, I
AU  - Medugorac I
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Basic Res Cardiol
JT  - Basic research in cardiology
JID - 0360342
RN  - 0 (Lactates)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Aging
MH  - Animals
MH  - Animals, Newborn
MH  - Cardiomegaly/*enzymology
MH  - Glucose/metabolism
MH  - Heart Ventricles/anatomy & histology
MH  - Hexokinase/metabolism
MH  - Hypoxia/enzymology
MH  - L-Lactate Dehydrogenase/metabolism
MH  - Lactates/metabolism
MH  - Myocardium/*enzymology
MH  - Organ Size
MH  - Rats
EDAT- 1980/01/01 00:00
MHDA- 1980/01/01 00:01
CRDT- 1980/01/01 00:00
PHST- 1980/01/01 00:00 [pubmed]
PHST- 1980/01/01 00:01 [medline]
PHST- 1980/01/01 00:00 [entrez]
AID - 10.1007/BF02001416 [doi]
PST - ppublish
SO  - Basic Res Cardiol. 1980 Jan-Feb;75(1):214-20. doi: 10.1007/BF02001416.