PMID- 6447753
OWN - NLM
STAT- MEDLINE
DCOM- 19801124
LR  - 20190508
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 152
IP  - 3
DP  - 1980 Sep 1
TI  - Cellular basis of graft versus host tolerance in chimeras prepared with total 
      lymphoid irradiation.
PG  - 736-41
AB  - BALB/c mice given allogeneic (C57BL/Ka) bone marrow cells after toal lymphoid 
      irradiation become stable chimeras approximately 80% donor-type and 20% host-type 
      cells in the spleen. The chimeras doe not develop graft vs. host disease (GVHD). 
      Purified cells of C57BL/Ka origin from the chimeras mediated GVHD in lightly 
      irradiated C3H (third party), but not in BALB/c (host-strain) mice. Thus graft 
      vs. host tolerance in the chimeras could not be explained by complete 
      immunodeficiency of donor-type cells, serum blocking factors, or suppressor cells 
      of host (BALB/c) origin. Clonal deletion or suppression of lymphocytes reactive 
      with host tissues remain possible explanations. The transfer of donor-type 
      chimeric spleen cells to BALB/c recipients given 500-550 rad whole-body 
      irradiation WBI led to stable mixed chimerism in approximately 50% of recipients. 
      The cells were presumably acting as tolerogens because similarly irradiated 
      BALB/c mice given (BALB/c X C57BL/Ka)F1 spleen or bone marrow cells also became 
      stable mixed chimeras.
FAU - Gottlieb, M
AU  - Gottlieb M
FAU - Strober, S
AU  - Strober S
FAU - Kaplan, H S
AU  - Kaplan HS
LA  - eng
GR  - AI 11313/AI/NIAID NIH HHS/United States
GR  - CA 10372/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
SB  - IM
MH  - Animals
MH  - *Graft vs Host Reaction
MH  - *Immune Tolerance
MH  - Mice
MH  - *Radiation Chimera
MH  - Spleen/immunology
MH  - T-Lymphocytes, Regulatory/*immunology
PMC - PMC2185928
EDAT- 1980/09/01 00:00
MHDA- 1980/09/01 00:01
PMCR- 1981/03/01
CRDT- 1980/09/01 00:00
PHST- 1980/09/01 00:00 [pubmed]
PHST- 1980/09/01 00:01 [medline]
PHST- 1980/09/01 00:00 [entrez]
PHST- 1981/03/01 00:00 [pmc-release]
AID - 81008393 [pii]
AID - 10.1084/jem.152.3.736 [doi]
PST - ppublish
SO  - J Exp Med. 1980 Sep 1;152(3):736-41. doi: 10.1084/jem.152.3.736.