PMID- 6452588
OWN - NLM
STAT- MEDLINE
DCOM- 19810613
LR  - 20190514
IS  - 0028-3878 (Print)
IS  - 0028-3878 (Linking)
VI  - 31
IP  - 4
DP  - 1981 Apr
TI  - Changes in immune response during responses in MS patients.
PG  - 492-5
AB  - Changes in clinical status and in two measures of immune function were followed 
      for 21 months (median) in 106 multiple sclerosis (MS) patients and cohabitant 
      controls. Antibody titers to measles, cytomegalovirus, and herpesvirus 1 and 2, 
      and leukocyte migration inhibition indexes (LMIs) to measles and 
      streptokinase/streptodornase (SKSD) were measured at 3- to 6-month intervals and 
      at time of exacerbation in the index case. There were 36 exacerbations in 25 
      patients. Mean baseline antibody titers and LMI to measles were higher in cases 
      than in controls. No consistent changes occurred in antibody titers to any of the 
      viruses, non in LMI to SKSD. LMIs to measles were lower in most MS patients 
      during exacerbations than before or after exacerbations. This apparent 
      improvement in cell-mediated immune response to measles only during exacerbations 
      may reflect aberrant immune regulation in MS patients, response to recrudescence 
      of a latent agent, or some other phenomenon as yet undefined.
FAU - Detels, R
AU  - Detels R
FAU - Myers, L W
AU  - Myers LW
FAU - Ellison, G W
AU  - Ellison GW
FAU - Visscher, B R
AU  - Visscher BR
FAU - Malmgren, R M
AU  - Malmgren RM
FAU - Madden, D L
AU  - Madden DL
FAU - Sever, J L
AU  - Sever JL
LA  - eng
GR  - 2R01 NS 10186/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0 (Antigens)
SB  - IM
MH  - *Antibody Formation
MH  - Antigens/immunology
MH  - Cell Migration Inhibition
MH  - Humans
MH  - Immunity, Cellular
MH  - Leukocytes/immunology
MH  - Measles virus/immunology
MH  - Multiple Sclerosis/*immunology
MH  - Recurrence
MH  - T-Lymphocytes, Regulatory/immunology
EDAT- 1981/04/01 00:00
MHDA- 1981/04/01 00:01
CRDT- 1981/04/01 00:00
PHST- 1981/04/01 00:00 [pubmed]
PHST- 1981/04/01 00:01 [medline]
PHST- 1981/04/01 00:00 [entrez]
AID - 10.1212/wnl.31.4.492 [doi]
PST - ppublish
SO  - Neurology. 1981 Apr;31(4):492-5. doi: 10.1212/wnl.31.4.492.